Publications by authors named "K T Muir"
Background And Objectives: Data from randomized trials on the treatment effect of pure thrombolysis in patients with vessel occlusion are lacking. We examined data from a corresponding subsample of patients from the multicenter, randomized, placebo-controlled WAKE-UP trial to determine whether MRI-guided IV thrombolysis with alteplase in unknown-onset ischemic stroke benefits patients presenting with vessel occlusion.
Methods: Patients with an acute ischemic lesion visible on MRI diffusion-weighted imaging but no marked parenchymal hyperintensity on fluid-attenuated inversion recovery images were randomized to treatment with IV alteplase or placebo.
Should we switch to tenecteplase for all ischemic strokes? Evidence and logistics.
Int J Stroke
January 2025
Recent clinical trials provide robust evidence of non-inferiority of tenecteplase 0.25 mg/kg over alteplase 0.9 mg/kg in acute ischemic stroke treated within 4.
View Article and Find Full Text PDFBackground: Patients with limited English proficiency (LEP) experience worse emergency department (ED) outcomes.
Purpose: To evaluate the association between nurses' work environments and ED outcomes among individuals with and without LEP.
Methods: Cross-sectional study of 1,358,802 patients seen in 64 New Jersey hospital EDs.
Article Synopsis
- Blood-brain barrier disruption in acute ischemic stroke is linked to complications, with GLOS indicating issues in the blood-ocular barrier.
- In a study of WAKE-UP trial patients, 29% showed GLOS, significantly more than the 7% with HARM.
- GLOS presence was associated with factors like age, renal function, and white matter hyperintensity but did not correlate with hemorrhagic transformation or functional outcomes.
Article Synopsis
- NOTCH3cys variants are common and linked to various small vessel diseases, including early-onset stroke and dementia, but there is no comprehensive staging system to assess their severity.
- A cohort study created and validated a simple staging system for NOTCH3-SVD by analyzing data from several international cohorts and the UK Biobank, focusing on the impact of these variants on CVD outcomes and cognition.
- The new system includes 9 disease stages, aiding in understanding the relationship between stages and clinical outcomes like ischemic strokes, cognitive function, and brain damage.