Performance of the ARC-HBR Criteria in ST-Elevation Myocardial Infarction. Significance of Smoking as an Additional Bleeding Risk Factor.

Background And Aims: The Academic Research Consortium for High Bleeding Risk Criteria (ARC-HBR) are recommended by guidelines for bleeding risk assessment in ST-elevation myocardial infarction (STEMI). The aim of this study was to identify possible other risk factors and adjust the original ARC-HBR criteria for confounders.

Methods: All consecutive STEMI patients managed in a Finnish tertiary hospital between 2016-2022 were identified using a database search.

The impact of IBD on ability to work and study: a patient perspective.

Purpose: The aim of this study was to explore the multifaceted ways in which inflammatory bowel disease (IBD) negatively affects working life and studies.

Material And Methods: IBD patients were identified by diagnosis codes from the hospital records of a Finnish University Hospital. Patients were sent questionnaires mail and text messages.

Does cytochrome 2D6 genotype affect the analgesic efficacy of codeine after ambulatory surgery? Prospective trial in 987 adults.

Background: Paracetamol-codeine combination tablet is widely used in pain management after day surgery. For safety reasons, its use has decreased in recent years. Codeine is a prodrug metabolised in the liver by the cytochrome P450 2D6 (CYP2D6) enzyme to morphine that produces the analgesic effect of codeine.

Imaging Outcomes of MRI After CT in Pediatric Spinal Trauma: A Single-center Experience.

Background: Imaging has an essential role in the diagnostic workup of suspected pediatric spinal trauma. The most suitable imaging method is still being debated and needs to be considered regarding the patient, injury, and local resources. Magnetic resonance imaging (MRI) is often performed after computed tomography (CT) in case of neurological symptoms or suspected ligamentous disruption.

Real-world results of first-line immunotherapy or targeted therapy for metastatic melanoma in Finland: a cohort study.

First-line (1L) immunotherapy has yielded superior overall survival (OS) in metastatic melanoma (MM) but some patients are ineligible for immunotherapy or need rapid response with 1L targeted therapy (TT). Retrospective cohort study of real-world patients treated with 1L immunotherapy (144 wild type, 85 -mutated) or 1L TT (143 -mutated) for MM in Finland during 2014-2021. Baseline brain metastases, liver metastases and elevated LDH were less common, 2-year OS rates were higher (60.