Publications by authors named "K T Kruse"

From cytoskeletal networks to tissues, many biological systems behave as active materials. Their composition and stress generation is affected by chemical reaction networks. In such systems, the coupling between mechanics and chemistry enables self-organization, for example, into waves.

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Article Synopsis
  • - The bone marrow microenvironment is crucial for regulating haematopoietic stem cell functions, and this study investigates whether different bone areas have unique properties and resilience, especially in the context of aging and inflammation.
  • - Researchers found that the skull's bone marrow grows and becomes more vascularized throughout life, contributing significantly to blood cell production and showing resistance to typical aging effects like inflammation and fat accumulation.
  • - The study highlights that changes in the skull’s bone marrow occur rapidly due to various conditions, including pregnancy and diseases like stroke, indicating that the skull offers a unique and adaptable environment compared to the more commonly studied femur.
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Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly understood. Here, we report a paradigm to quantify phenotypic diversity in head and neck squamous cell carcinoma (HNSCC) with single-cell resolution.

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Stress generation by the actin cytoskeleton shapes cells and tissues. Despite impressive progress in live imaging and quantitative physical descriptions of cytoskeletal network dynamics, the connection between processes at molecular scales and spatiotemporal patterns at the cellular scale is still unclear. Here, we review studies reporting actomyosin clusters of micrometre size and with lifetimes of several minutes in a large number of organisms, ranging from fission yeast to humans.

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Oral inorganic nitrate ([Formula: see text]) supplementation increases nitric oxide (NO) bioavailability and may improve muscular power in males and females, although data in females are limited. Estrogen increases NO bioavailability and fluctuates throughout the menstrual cycle, with low levels in the early follicular (EF) phase and peaking during the late follicular (LF) phase. The purpose of the present study was to examine the effects of [Formula: see text] supplementation on isokinetic peak power, maximal voluntary isometric contraction (MVIC) force, muscular endurance, and recovery from fatigue in healthy young females during the EF and LF phases of the menstrual cycle.

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