Publications by authors named "K T Korn"
Article Synopsis
- Monkeypox virus (MPXV) caused a significant outbreak in 2022, with over 90,000 cases and 181 fatalities, exhibiting signs of evolution and adaptation to hosts.
- Research revealed that different MPXV isolates from the Franconia region have mutations affecting their replication capabilities, particularly a variant with a mutation (D616L) that shows faster viral replication.
- The study also found that dihydroorotate dehydrogenase (DHODH) inhibitors are effective against MPXV and related viruses, offering promising low-toxicity options for future antiviral drug development.
Article Synopsis
- - Our study reveals that HIV infection affects vaccine-induced immunity by reducing the effectiveness of specific CD4 T cells, linked to high levels of inflammatory signals and altered T cell composition.
- - We discovered that the CD4 T cells from HIV-infected individuals show reduced expression of key genes associated with protective immunity from vaccines, along with impaired response pathways for important immune signals like IFNα and IFNγ.
- - Importantly, reducing inflammation in HIV-infected patients using certain drugs improved the immune response of memory CD4 T cells, suggesting that managing inflammation could enhance vaccine efficacy in these individuals.
Article Synopsis
- - Human herpesvirus-8 (HHV-8), linked to Kaposi's sarcoma (KS), is more prevalent in individuals co-infected with HIV-1, especially in sub-Saharan African men, making it common among this group prior to the HIV-1 epidemic.
- - Researchers tested 58 HHV-8-positive serum samples for antibodies targeting specific glycoproteins and found that neutralizing capacity increases during KS remission, with heightened antibodies against glycoprotein K8.1 during both active disease and remission.
- - The study suggests that glycoproteins like gHgL could be key targets for neutralizing antibodies, and recovery from KS might be linked to enhanced neutralizing capacity, indicating a
Virologic failure of long-acting rilpivirine/cabotegravir is rare but may result in severely limited treatment options. Known risk factors cannot predict all cases. Therapeutic drug monitoring (TDM) may help identify patients at risk, but reliable thresholds are missing.
View Article and Find Full Text PDFBorna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon). The known BoDV-1-endemic area is remarkably restricted to parts of Germany, Austria, Switzerland and Liechtenstein. To gain comprehensive data on its occurrence, we analysed diagnostic material from suspected BoDV-1-induced encephalitis cases based on clinical and/or histopathological diagnosis.
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