Publications by authors named "K T Hornberger"
Background: The following case report details the genetic evaluation and treatment of a 30-year-old male with a history of asthenoteratospermia and notable abnormalities of the sperm flagella.
Methods: Genetic evaluation was performed via a multi-gene panel of genes associated with primary ciliary dyskinesia and multiple morphological abnormalities of the sperm flagella (MMAF) prior to the couple's in vitro fertilization (IVF) cycle.
Results: Genetic evaluation was performed via a multi-gene panel of genes associated with primary ciliary dyskinesia and multiple morphological abnormalities of the sperm flagella (MMAF) prior to the couple's in vitro fertilization (IVF) cycle.
Article Synopsis
- Optical binding is the interaction between objects affected by laser light, useful for controlling tiny mechanical movements.
- The study explores the quantum aspects of optical binding and how these effects can be detected in upcoming experiments with levitated nanoparticles.
- The research also highlights limitations in achieving entanglement through optical binding in free space and suggests methods to overcome these challenges.
Article Synopsis
- Matter-wave interferometry with molecules showcases a key quantum phenomenon and has potential for advanced measurements in physical chemistry.
- A major challenge is developing efficient beam splitting methods that can work with a variety of particles.
- This research focuses on using intense deep-ultraviolet light to better understand interactions that could lead to new techniques in protein interferometry and enhanced sensing of molecular properties.
Non-Hermitian dynamics, as observed in photonic, atomic, electrical and optomechanical platforms, holds great potential for sensing applications and signal processing. Recently, fully tuneable non-reciprocal optical interaction has been demonstrated between levitated nanoparticles. Here we use this tunability to investigate the collective non-Hermitian dynamics of two non-reciprocally and nonlinearly interacting nanoparticles.
View Article and Find Full Text PDFCellular therapies for the treatment of human diseases, such as chimeric antigen receptor (CAR) T and natural killer (NK) cells have shown remarkable clinical efficacy in treating hematological malignancies; however, current methods mainly utilize viral vectors that are limited by their cargo size capacities, high cost, and long timelines for production of clinical reagent. Delivery of genetic cargo via DNA transposon engineering is a more timely and cost-effective approach, yet has been held back by less efficient integration rates. Here, we report the development of a novel hyperactive TcBuster (TcB-M) transposase engineered through structure-guided and in vitro evolution approaches that achieves high-efficiency integration of large, multicistronic CAR-expression cassettes in primary human cells.
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