Publications by authors named "K T Godder"
Hematopoietic cell transplantation (HCT) uses cytotoxic chemotherapy and/or radiation followed by intravenous infusion of stem cells to cure malignancies, bone marrow failure and inborn errors of immunity, hemoglobin and metabolism. Lung injury is a known complication of the process, due in part to disruption in the pulmonary microenvironment by insults such as infection, alloreactive inflammation and cellular toxicity. How microorganisms, immunity and the respiratory epithelium interact to contribute to lung injury is uncertain, limiting the development of prevention and treatment strategies.
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- Lung injury is really important for kids' survival after getting special treatments for blood diseases, and scientists want to learn more about how germs and the body work together in the lungs.
- In a big study, researchers looked at lung samples from 229 kids at 32 hospitals over 8 years and found 4 different groups of patients based on their lung microbe makeup.
- Each group had different health outcomes: one group had low infection rates and low death rates, while others had high infection and death rates, showing that the type of lung microbes can greatly affect survival.
Mediators of Social Acceptance Among Emerging Adult Survivors of Childhood Cancer.
J Adolesc Young Adult Oncol
October 2023
Examine associations of social developmental factors (e.g., peer/parent social attachment, romantic relationships) and perceptions of social acceptance among emerging adult survivors of childhood cancer.
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- G-CSF after hematopoietic stem cell transplantation (HSCT) improves neutrophil recovery in neutropenic patients, but its safety in sickle cell disease (SCD) patients was previously unknown.
- Clinical outcomes were studied in 62 SCD patients receiving G-CSF post-HSCT, showing effective neutrophil and platelet engraftment without any SCD-related complications.
- Common post-treatment issues included anorexia, hypertension, and electrolyte imbalances, but overall, G-CSF was determined to be safe for SCD patients following HSCT.
Importance: Although effective agents are available to prevent painful vaso-occlusive episodes of sickle cell disease (SCD), there are no disease-modifying therapies for ongoing painful vaso-occlusive episodes; treatment remains supportive. A previous phase 3 trial of poloxamer 188 reported shortened duration of painful vaso-occlusive episodes in SCD, particularly in children and participants treated with hydroxyurea.
Objective: To reassess the efficacy of poloxamer 188 for vaso-occlusive episodes.