Publications by authors named "K T Britton"
Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS have not been evaluated for developmental toxicity potential. A concentration-response study of 182 unique PFAS chemicals using the zebrafish medium-throughput, developmental vertebrate toxicity assay was conducted to investigate chemical structural identifiers for toxicity.
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- The study explores the need for non-invasive methods to detect amyloid-β pathology in Alzheimer’s disease, especially with new treatments available.
- It evaluates the effectiveness of plasma tau phosphorylated at threonine-217 (P-tau217) as a potential alternative for determining eligibility for DMTs like aducanumab.
- Results indicate that elevated P-tau217 levels strongly predict Aβ positivity, suggesting that this method could efficiently identify candidates for treatment while also highlighting the complexity of cutoff levels needed for accurate diagnoses.
Article Synopsis
- This study examined how calorie restriction (CR) affects the elemental content and stable isotope ratios in bone collagen and hair keratin in adult mice over a period of 84 days.
- Mice on higher CR (10-40%) showed decreased nitrogen, carbon, and sulfur levels in their hair, while bone collagen nitrogen levels increased and carbon levels decreased.
- The findings suggest that changes in the structure of bone collagen and the mobilization of proteins during CR complicate the use of elemental measurements for assessing collagen quality in archaeological contexts, especially where nutrition might be a concern.
: To examine relationships between sleep, alcohol consumption, and a physiological and behavioral marker of cognitive function in college students. College students are in a high risk category for high alcohol consumption and poor sleep quality, two unhealthful behaviors which can lead to poor mental health outcomes and compromised academic performance. : Thirty college students from a large midwestern institution.
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- The study investigates non-invasive methods for detecting amyloid-β pathology in early Alzheimer's disease, focusing on the use of plasma tau phosphorylated at threonine-217 (P-tau217) as a potential alternative to costly and invasive techniques like PET and CSF analysis.
- Researchers developed specific P-tau217 cutoffs and tested them on candidates from a memory and aging program, using ROC analysis to assess diagnostic accuracy against established methods.
- Results showed high predictive accuracy of P-tau217 for identifying Aβ positivity, with a significant portion of candidates being treated with aducanumab, indicating that these cutoff strategies could improve access to disease-modifying treatments.