Publications by authors named "K T B Knoops"
Enteroendocrine cells (EECs) are gut epithelial cells that respond to intestinal contents by secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric inhibitory protein (GIP), which regulate multiple physiological processes. Hormone release is controlled through metabolite-sensing proteins. Low expression, interspecies differences, and the existence of multiple EEC subtypes have posed challenges to the study of these sensors.
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- - This study explores a novel method for creating vascular networks in 3D microtissues using microwell arrays made from thin polymer films, which can be non-porous or porous.
- - The researchers use two different configurations for cultivating endothelial cells: one with cells growing inside non-porous wells and another with cells on the outside of porous wells, allowing them to sprout inward.
- - The results successfully demonstrate vascularization in spheroids made from human stem cells and osteosarcoma cells, indicating that these methods can generate robust vascular networks needed for functional tissue engineering.
Long-term remission of Hailey-Hailey disease by Er:YAG ablative laser therapy.
J Eur Acad Dermatol Venereol
October 2024
Background: Hailey-Hailey disease (HHD) is a rare genetic therapy-resistant blistering disease with great disease burden. Treatment is currently focused on symptomatic relief. Er:YAG ablative laser therapy is a therapeutic modality with promising results, though evidence is currently scarce.
View Article and Find Full Text PDFNeurodegenerative disorders are characterized by the progressive loss of structure and function of neurons, often including the death of the neuron. Previously, we reported that, by removing the cell death stimulus, dying/injured neurons could survive and recover from the process of regulated cell death, even if the cells already displayed various signs of cellular damage. Now we investigated the role of mitochondrial dynamics (fission/fusion, biogenesis, mitophagy) in both degeneration and in recovery of neuronal cells.
View Article and Find Full Text PDFChorioamnionitis is a risk factor for necrotizing enterocolitis (NEC). (UP) is clinically the most isolated microorganism in chorioamnionitis, but its pathogenicity remains debated. Chorioamnionitis is associated with ileal barrier changes, but colonic barrier alterations, including those of the mucus barrier, remain under-investigated, despite their importance in NEC pathophysiology.
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