[Effect of ATP infusion on heart function in the post-perfusion period after aortocoronary bypass surgery in patients with chronic ischemic heart disease].

Using thermodilution technique, 110 patients have been examined during aortocoronary bypass surgery. Cardiac output, pump coefficient, cardiac index, stroke index, mean and edge pulmonary pressure, and other parameters of peripheral hemodynamics have been determined. At the end of the operation upon heart function recovery the test patients were administered intravenously a 1% ATP solution at a dose of 0.

[The effect of exogenously administered ATP on the postischemic restoration of myocardial function].

The effect of ATP (24 x 10(-6) M) on the contractility of the isolated hearts has been studied. It has been shown that ATP infusions improved postischemic hemodynamics. The favourable effect of ATP was based on the retention of diastolic properties and compliance of the left ventricle.

[Potentialities of ATP in sustaining the function of the myocardium].

The effect of ATP on the functional capacities of the isolated heart has been assessed. It has been shown that the drug at a concentration of 24 x 10(-6) M improves myocardial contractility and increases coronary flow volumetric rate. Favourable ATP effects manifested right after its administration into the circulating solution in improvement of all the physiological parameters, but were unstable.

[Combined use of non-depolarizing muscle relaxants in clinical anesthesiology].

Clinical observations in 99 patients and 74 experiments in cats enabled the authors to suggest that nondepolarizing myorelaxants when used in combination affected different portions of cholinergic receptors of the end plate of motor nerves causing greater inhibition of neuromuscular transmission. So an associated simultaneous application of such myorelaxants as tubocurarine and tercuronium as well as tercuronium and Arduan in special sub-blocking doses gives a complete relaxation of skeletal muscles without side effects which allows such methods to be recommended in surgical practice for anesthetic maintenance of operations on high risk patients.