Histone-binding protein RBBP4 is necessary to promote neurogenesis in the developing mouse neocortical progenitors.

Chromatin regulation plays a crucial role in neocortical neurogenesis, and mutations in chromatin modifiers are linked to neurodevelopmental disorders. RBBP4 is a core subunit of several chromatin-modifying complexes; however, its functional role and genome-wide occupancy profile in the neocortical primordium are unknown. To address this, we performed RBBP4 knockdown using CRISPR/Cas9 on neocortical progenitors derived from mice of both sexes at embryonic age 12.

National Service Scheme (NSS) Training in dental education: Assessment of self reported empathy and clinical performance.

Background: To compare self-reported empathy scores, clinical performance between National Service Scheme (NSS) volunteers and non-volunteers in dental schools; and to predict clinical performance score using self-reported empathy score.

Material And Methods: A cross sectional survey of 336 undergraduates from 16 dental schools in Andhra Pradesh state, India was conducted using Google forms. The questionnaire was divided into four sections.

An interpretable and transparent machine learning framework for appendicitis detection in pediatric patients.

Appendicitis, an infection and inflammation of the appendix is a prevalent condition in children that requires immediate treatment. Rupture of the appendix may lead to several complications, such as peritonitis and sepsis. Appendicitis is medically diagnosed using urine, blood, and imaging tests.

SADXAI: Predicting social anxiety disorder using multiple interpretable artificial intelligence techniques.

Social anxiety disorder (SAD), also known as social phobia, is a psychological condition in which a person has a persistent and overwhelming fear of being negatively judged or observed by other individuals. This fear can affect them at work, in relationships and other social activities. The intricate combination of several environmental and biological factors is the reason for the onset of this mental condition.