Identification of steroidal cardenolides from Calotropis procera as novel HIV-1 PR inhibitors: A molecular docking & molecular dynamics simulation study.

Background & objectives Despite advancements in antiretroviral therapy, drug-resistant strains of HIV (human immunodeficiency virus) remain a global health concern. Natural compounds from medicinal plants offer a promising avenue for developing new HIV-1 PR (protease) inhibitors. This study aimed to explore the potential of compounds derived from Calotropis procera, a medicinal plant, as inhibitors of HIV-1 PR.

Colour tunable photoluminescence studies of Dy/Eu co-doped BaPbAlFB glasses for epoxy-free w-LED applications.

Barium lead alumino fluoroborate (BaPbAlFB) glasses singly and co-doped with Dy and Eu ions were prepared by melt quench method and studied their photoluminescence (PL) properties along with energy migration. Singly doped Dy/Eu ions in BaPbAlFB glasses under 365 and 393 nm excitation wavelengths emit the PL bands through Dy: (F → H and F → H) and Eu: (D→F) transitions located at (Dy: 483 and 575 nm) and (Eu: 613 nm) respectively. Further, tunability of PL emissions is achieved by exciting the Dy/Eu co-doped BaPbAlFB glasses at various wavelengths.

Structural Investigation and Optical Properties of Dysprosium (Dy) Ions Doped Oxyfluoro Antimony Borate Glasses for Photonics Applications.

Dysprosium oxide-doped glasses with a composition of 60BO-10SbO-10AlO-10NaF-(10-x) LiF-xDyO (x = 0.1,0.5, 1.

White light emission from Dy-doped ZnO + BiO + BaF + BO + TeO glasses: Structural and spectroscopic properties.

The ZnO + BiO + BaF + BO + TeO (ZnBiBaBFTe) host glass was prepared by melt quenching technique with the aim of achieving white light emission from Dy ions. Their structural and spectroscopic properties were systemically investigated by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), UV-Visible absorption, emission spectra and decay times. Judd-Ofelt (JO) parameters (Ω) evaluated from absorption spectrum were utilized to calculate the radiative parameters for F level of Dy ions.

Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats.

In the current study, we evaluated the effects of Asiatic acid (AA) on lipid metabolic markers in HFD-induced obese Sprague-Dawley rat model. AA (20 mg/kg BW) was administered orally to HFD-fed rats for 42 days. Changes in body composition, glucose, insulin resistance (IR) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and its target genes fatty-acid synthase (FAS), adipocyte protein-2 (aP2) and uncoupling protein-2 (UCP-2) and pro-inflammatory factor tumor necrosis factor (TNF)-α were observed in experimental rats.