Colorectal polyps increase the glycolytic activity.

In colorectal cancer (CRC) energy metabolism research, the precancerous stage of polyp has remained rather unexplored. By now, it has been shown that CRC has not fully obtained the glycolytic phenotype proposed by O. Warburg and rather depends on mitochondrial respiration.

Mitochondrial Respiration in and Mutated Colorectal Tumors and Polyps.

This study aimed to characterize the ATP-synthesis by oxidative phosphorylation in colorectal cancer (CRC) and premalignant colon polyps in relation to molecular biomarkers KRAS and BRAF. This prospective study included 48 patients. Resected colorectal polyps and postoperative CRC tissue with adjacent normal tissue (control) were collected.

A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia.

The hepatitis C virus (HCV)-infected patients serve as a reservoir for transmission of the disease to others and are at risk of developing chronic hepatitis C, cirrhosis, and hepatocellular carcinoma. Although the epidemiological data of high rate HCV infection have been obtained in many countries, such data are insufficient in Estonia. Therefore, the aim of the study was to analyze country-specific data on HCV patients.

[Prevalence of selective lactose malabsorption in Khants].

The aim of the study was to determine the prevalence of selective lactose malabsorption (SLM) in Khants, a small finno-ugric nation living in West Siberia. A total of 80 Khants from the Surgut region (Tyumen territory) were studied. The diagnosis of SLM was based on the evidence obtained at a 50 g lactose and, if possible, a 25 g + 25 g galactose-glucose loads.

Lactose malabsorption in Khants in western Siberia.

Background: We wanted to estimate the prevalence of selective lactose malabsorption (SLM) in Khants, a small Finno-Ugric population living in Western Siberia who have traditionally consumed no milk in adulthood.

Methods: A total of 80 Khants, aged 8-57 years and living on the middle reaches of the River Ob, were studied. The diagnosis was based on a lactose tolerance test; general malabsorption was excluded by a glucose-galactose tolerance test whenever possible.