Targeted delivery of DAPT using dual antibody functionalized solid lipid nanoparticles for enhanced anti-tumour activity against triple negative breast cancer.

Triple-negative breast cancer (TNBC) is a subtype known for its aggressive nature, high rates of recurrence, and treatment resistance, largely attributed to the presence of breast cancer stem cells (BCSCs). Traditional therapies often struggle to eliminate BCSCs, which contributes to tumor recurrence. One promising strategy for addressing this challenge is targeting the Notch signaling pathway, which plays a critical role in the self-renewal and maintenance of BCSCs.

Production, Purification and Immobilization of Laccase from HBB 7328 for its Role in Decolorization of Textile Dyes.

Laccase is an extracellular enzyme that is widely used in the decolonization of textile dyes in waste water. The aim of our study was to isolate, purify, characterize and immobilize the laccase enzyme produced by HBB 7328. Purified laccase enzyme was immobilized in polyacrylamide gel to explore its ability in decolonization of textile dyes.

Meta-analysis on Effectiveness of Palliative Care versus Conventional Care amongst Advanced Gynaecological Patients with Cancer and Caregivers.

In cancer patients, physical and psychological issues are very common. There is a need for family support and high utilisation of healthcare resources commonly. Palliative care (PC) has grown in popularity to better fulfil of needs of patients and their families and potentially lowering hospital costs.

Tailoring the photoluminescence of AIE-type gold nanoclusters biomineralization-inspired polymorphism.

Tailoring the aggregation-induced emission (AIE) characteristics of well-defined metal nanoclusters (MNCs) is highly sought after for numerous practical applications. Studies have primarily focused on assembling AIE-type MNCs using monomorphic molecules. Achieving polymorphic assemblies, with different molecular arrangements could provide valuable insights into the role of external molecular matrices on the photoluminescence (PL) behaviour of these NCs.