Publications by authors named "K Sunakawa"
Ilmenite, FeTiO, is a common mineral in nature, existing as an accessory phase in the most basic igneous and metamorphic rocks, for example, it is derived from the upper mantle. Therefore, an understanding of the high-pressure physics of FeTiO is of fundamental importance in the study of rock magnetization. Here, we provide experimental evidence of lattice compression of FeTiO powder using super-high-energy ball milling, enabling the very high collision energy of 420 times gravitational acceleration.
View Article and Find Full Text PDFBackground: Meropenem is widely used for the treatment of paediatric patients with bacterial meningitis, but the pharmacodynamic (PD) basis for this has not been fully elucidated.
Objectives: A cerebrospinal pharmacokinetic (PK) and PD analysis was performed to identify the optimal dosage regimen for paediatric patients with inflamed central nervous system disease (bacterial men-ingitis).
Patients And Methods: Paediatric data from three clinical studies were used to build a novel population PK model with a cerebrospinal fluid (CSF) compartment, assuming CSF clearance of 0.
Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility.
J Infect Chemother
September 2017
Article Synopsis
- A nationwide study in Japan in 2012 focused on monitoring the antibiotic resistance of bacterial pathogens responsible for respiratory infections in adult patients.
- A total of 1,236 bacterial strains were tested, revealing high resistance rates, including 51.3% methicillin-resistant Staphylococcus aureus and concerning levels of antibiotic resistance in other bacteria like Klebsiella pneumoniae and Pseudomonas aeruginosa.
- The findings highlight the importance of ongoing surveillance to understand and address the increasing resistance of bacterial respiratory pathogens to antimicrobial treatments.
Unlabelled: The pharmacokinetic characteristics of liposomal amphotericin B (L-AMB; AmBisome(®)) in patients with invasive fungal infection were investigated. A population pharmacokinetic (PK) model in Japanese pediatric patients was developed based on 159 serum amphotericin B (AMPH-B) concentrations obtained in a post-marketing clinical study. The subjects were 39 patients with a mean age of 8.
View Article and Find Full Text PDFBackground: Streptococcus pneumoniae is a major causative pathogen of pneumonia in children. The Drug-Resistant Pathogen Surveillance Group in Pediatric Infectious Disease conducted a nationwide surveillance of S. pneumoniae in 2000-2001, 2004, 2007, 2010 and 2012, and investigated changes in drug resistance of S.
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