Publications by authors named "K Sumiyoshi"
Article Synopsis
- Effective blood sampling times for vancomycin AUC estimation have not been clearly defined, prompting this study to explore different sampling times during dosing intervals.
- Six participants were studied after receiving intravenous vancomycin, with AUC estimated using various software and models, assessing accuracy through bias and imprecision.
- The study identified optimal blood sampling times of 2.5 and 5.5 hours post-injection for certain software, suggesting improved therapeutic drug monitoring could result from standardized sampling times.
Article Synopsis
- - The study explores how NSCLC patients with poor performance status and symptomatic brain metastases can benefit from upfront intracranial treatment, potentially leading to improved overall survival.
- - Data from 50 patients showed that those treated with tyrosine kinase inhibitors (TKI) or immune checkpoint inhibitors (ICI) had better median survival rates (19 months) than those receiving chemotherapy alone (13 months).
- - Results suggest that even patients initially deemed unsuitable for ICI may experience improved survival with personalized treatment approaches, evidenced by significant differences in outcomes based on the type of systemic therapy chosen.
Introduction: Aromatase inhibitor (AI)-induced musculoskeletal symptoms (AIMSS) can decrease health-related quality of life and lead to discontinuation of AI therapy for postmenopausal women with breast cancer (BC). Although central sensitization (CS) may contribute to AIMSS, the relevance of CS-related symptoms to AIMSS has not been fully clarified. This study aimed to investigate the relationship between AIMSS and CS-related symptoms in women with BC who received AI therapy.
View Article and Find Full Text PDFThe development of high-performance Fe-based catalysts is attractive because Fe is a cost-effective and earth-abundant element. Application of an external electric field and an appropriate catalytic support to an Fe-based catalyst enabled the reverse water-gas shift reaction to proceed with high activity, selectivity, and durability even at the low temperature of 423 K. The Fe-supported catalyst showed superior CO selectivity (≈ 100%) compared to the Co- or Ni-supported catalyst.
View Article and Find Full Text PDFPurpose: Chemotherapy-induced peripheral neuropathy (CIPN) commonly involves hand dexterity impairment. However, the factors affecting hand dexterity impairment are unknown and there is currently no established treatment. The purpose of the current study was to clarify factors influencing hand dexterity impairment in taxane-induced peripheral neuropathy using subjective and objective assessments.
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