Publications by authors named "K Sumide"
Article Synopsis
- Researchers identified CD34-negative severe combined immunodeficiency (SCID)-repopulating cells as primitive hematopoietic stem cells in human cord blood.
- Using a new ultra-high-resolution purification method with positive markers CD133 and GPI-80, the study successfully isolated single long-term repopulating CD34 HSCs.
- The purified CD34 HSCs exhibited a distinct molecular signature and a strong ability to differentiate into megakaryocyte/erythrocyte progenitors, suggesting a new pathway for their commitment from cord blood.
It is generally thought that the proliferative capacity and differentiation potential of somatic stem cells, including mesenchymal stromal/stem cells (MSCs) and hematopoietic stem cells, decline with age. We investigated the effects of aging on human bone-derived MSCs expressing CD271 and SSEA-4 (double-positive MSCs [DPMSCs]). The percentages of DPMSCs in bone tissue decreased significantly with age.
View Article and Find Full Text PDFIn the murine hematopoietic stem cell (HSC) compartment, thrombopoietin (THPO)/MPL (THPO receptor) signaling plays an important role in the maintenance of adult quiescent HSCs. However, the role of THPO/MPL signaling in the human primitive HSC compartment has not yet been elucidated. We have identified very primitive human cord blood (CB)-derived CD34- severe combined immunodeficiency (SCID)-repopulating cells (SRCs) using the intra-bone marrow injection method.
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