Publications by authors named "K Sumathi Nitin"
Pentoxifylline (PTX) is a widely used pharmacological agent for the selection of motile sperm in both normozoospermic and asthenozoospermic ejaculates prior to their use in assisted reproductive technologies (ARTs), e.g. intracytoplasmic sperm injection (ICSI).
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- Fertility is influenced by various sperm functions, with poor motility being a leading cause of male infertility due to its dependence on cAMP signaling which is broken down by phosphodiesterases (PDEs).
- PDE inhibitors, like pentoxifylline (PTX), are used to enhance sperm motility in assisted reproduction technologies, but they can have negative side effects, such as causing premature acrosome reactions.
- The study reveals that theophylline (TP) binds to the same site as PTX with greater affinity, suggesting potential for TP as a fertility treatment, although its inhibitory mechanism remains unknown.
Proxy-approach in understanding the bisubstrate activity of strictosidine synthases.
Int J Biol Macromol
March 2024
Article Synopsis
- The study focuses on the Pictet-Spengler reaction catalyzed by strictosidine synthases (STR), examining how various substrates, including tryptamine, interact with STRs from two plant sources.
- Using isothermal titration calorimetry, the research identified different binding properties such as order and cooperativity, finding that OpSTR shows stronger cooperative binding than RsSTR.
- Additionally, crystallographic studies and molecular dynamics simulations were employed to explore substrate interactions and the effects of pH, with implications for drug design and enzyme engineering.
Background: Cotadutide is a dual glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptor agonist peptide. The objective of this analysis was to develop a population pharmacokinetic (popPK) model of cotadutide, and to identify any potential effect on the PK from intrinsic and extrinsic covariates.
Methods: The popPK analysis utilized a non-linear mixed-effects modeling approach using the data from 10 clinical studies in different participant categories following once-daily subcutaneous dose administration ranging from 20 to 600 μg.
ESI Clinical Practice Guidelines for the Evaluation and Management of Obesity In India.
Indian J Endocrinol Metab
September 2022