Publications by authors named "K Sugioka"
Article Synopsis
- - Chondroitin has been found to extend both lifespan and healthspan in the model organism C. elegans, but how it interacts with anti-aging processes inside cells is not fully understood.
- - The study reveals that chondroitin plays a crucial role in aging by promoting the formation of hemidesmosomes and preventing the excessive formation of tubular lysosomes that are linked to aging.
- - A mutation in the gene that produces chondroitin leads to earlier aging signs, specifically through excessive tubular lysosome formation, while the VHA-7 protein helps mitigate the effects of such mutations, indicating a potential new anti-aging mechanism controlled by the extracellular matrix.
Introduction: This report describes a case of necrotizing scleritis caused by infection soon after vitreous surgery, which caused severe scleral melting and rapidly progressive necrosis that led to scleral perforation and bacterial endophthalmitis.
Case Presentation: The patient was an 86-year-old man with a history of type 2 diabetes mellitus who underwent pars plana vitrectomy (PPV) for vitreous hemorrhage in his right eye. On postoperative day 10, he complained of severe ocular pain and was found to have conjunctival edema and eyelid swelling, which was treated by topical and general systemic antibiotics.
Foturan glass is a photosensitive transparent material which has attracted much interest for microfluidic applications due to possibility of volume processing by ultrafast lasers. In this work, we have investigated the effect of picosecond laser on volume processing in Foturan glass when varying the beam diameter incident on a lens. To this end, specific laser focusing configurations have been designed using raytracing models and an analysis protocol has been developed in the lens focusing region in order to describe the focal point displacement occurring at the variation of the incident laser beam diameter.
View Article and Find Full Text PDFCorneal fibroblasts maintain homeostasis of the corneal stroma by mediating the synthesis and degradation of extracellular collagen, and these actions are promoted by transforming growth factor-β (TGF-β) and interleukin-1β (IL-1β), respectively. The cornea is densely innervated with sensory nerve fibers that are not only responsible for sensation but also required for physiological processes such as tear secretion and wound healing. Loss or dysfunction of corneal nerves thus impairs corneal epithelial wound healing and can lead to neurotrophic keratopathy.
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