Publications by authors named "K Sugimori"

Peroral cholangioscopy (POCS) is valuable for assessing malignant biliary strictures; however, biliary drainage prior to POCS often hinders accurate diagnosis. This retrospective study aimed to investigate the feasibility of POCS using a newly developed cholangioscope, CHF-B290, during initial endoscopic retrograde cholangiopancreatography (ERCP) for malignant biliary strictures. This multicenter retrospective study included patients who underwent initial ERCP for malignant biliary strictures at two institutions between January 2018 and March 2022.

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Background: Recent advances in cancer genome analysis and the practice of precision medicine have made it possible to identify fractions with rare genetic alterations. Among biliary tract cancers, EGFR-amplified cancers are known to be rare fractions across organs and have a poor prognosis. The use of anti-EGFR antibody for EGFR-amplified cancers has been promising; however, the evidence is not yet clear.

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An 87-year-old woman was hospitalized for liver abscesses and cholangitis due to common bile duct stones. She developed worsening anemia and abdominal pain. Contrast-enhanced computed tomography revealed an intrahepatic pseudoaneurysm and an arteriovenous fistula between the hepatic arteries and inferior vena cava.

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Article Synopsis
  • The study aimed to assess the effectiveness and safety of nanvuranlat, an L-type amino acid transporter 1 inhibitor, as a treatment for advanced biliary tract cancers that are hard to treat.
  • Conducted across 14 Japanese medical centers, the trial involved 211 patients, with 105 eligible participants randomly assigned to receive either nanvuranlat or a placebo, focusing on progression-free survival (PFS) as the main measure of success.
  • Results showed that nanvuranlat significantly improved PFS compared to placebo, although overall survival rates were similar, suggesting the need for further research, especially in specific cancer subtypes like intrahepatic and extrahepatic cholangiocarcinoma.
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