Publications by authors named "K Sugata"
Background: T-SPOT.TB, one of the screening tests for latent tuberculosis infection (LTBI), yields invalid results in human T-cell leukemia virus type 1 (HTLV-1)-positive patients with rheumatoid arthritis. However, the detailed mechanisms behind this invalidation are unclear.
View Article and Find Full Text PDFArticle Synopsis
- - HTLV-1 can quickly transform CD4+ T cells in a lab setting, but most infected people remain asymptomatic, indicating a balance between the virus and the host's immune response.
- - The study found a variant in the HTLV-1 Tax301-309 viral antigen in individuals with a specific HLA-A24 type, which affected the detection of anti-Tax cytotoxic T cells (CTLs).
- - More than half of the T-cell receptors (TCRs) from these anti-Tax CTLs failed to recognize the mismatched Tax301-309 peptides, underlining the need for precise matching of viral antigens in T-cell therapy for adult T-cell leukemia (ATL).
Human immunodeficiency virus 1 (HIV-1) infection is characterized by a dynamic and persistent state of viral replication that overwhelms the host immune system in the absence of antiretroviral therapy (ART). The impact of prolonged treatment on the antiviral efficacy of HIV-1-specific CD8 T cells has nonetheless remained unknown. Here, we used single-cell technologies to address this issue in a cohort of aging individuals infected early during the pandemic and subsequently treated with continuous ART.
View Article and Find Full Text PDFBackground: Highly transmissible viruses including SARS-CoV-2 frequently accumulate novel mutations that are detected via high-throughput sequencing. However, there is a need to develop an alternative rapid and non-expensive approach. Here we developed a novel multiplex DNA detection method Intelli-OVI for analysing existing and novel mutations of SARS-CoV-2.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on understanding how HIV-1 latency is established and maintained, which is crucial for targeting the virus effectively.
- - Researchers introduced a new model called HIV-Timer of cell kinetics and activity (HIV-Tocky) that uses dual fluorescence to track HIV provirus silencing and reactivation, allowing for a better analysis of latent HIV populations.
- - The HIV-Tocky model distinguishes between two types of latent cells: those that are directly latent and those that have recently silenced, thereby enhancing our understanding of HIV reservoirs and potential treatment strategies to eliminate the virus.