Publications by authors named "K Sueyoshi"
Article Synopsis
- - Glycolipid antigens are recognized by CD1d on antigen-presenting cells and trigger immune responses in NKT cells through cytokine release.
- - The study discovered a specific glycolipid (α-GalCer nitro-type) that selectively induces Th2 and Th17 cytokines and has a strong binding affinity to CD1d due to modified fatty acyl groups.
- - The introduction of natural nitroalkene groups in these glycolipids enhances their interaction with CD1d, which helps explain their unique role in cytokine induction and selectivity.
Background The production of inflammatory cytokines is reportedly increased in patients with coronavirus disease 2019 (COVID-19), causing the migration of neutrophils and monocytes to lung tissues. This disrupts the air-blood barrier by damaging the bronchial epithelial and vascular endothelial cells. As multiorgan dysfunction in sepsis is considered to be partly caused by complement activation, which can cause lung injury in patients with COVID-19.
View Article and Find Full Text PDFIn this study, a structure-induced aptamer targeting small molecules was selected using capillary sieving electrophoresis (CSE). CSE was conducted using a capillary filled with a background solution containing hydroxypropyl cellulose as a sieving matrix to separate the aptamer candidates by changing their structures via complexation. Before aptamer selection, the original random-sequence DNA library was used to create structure-not-preorganized DNA sub-library containing straight-chain-like structures using CSE.
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