Publications by authors named "K Steib"
Article Synopsis
- The Sox11 gene is crucial for neurodevelopment, affecting processes like neuron survival and growth, but its activity regulation is not well understood.
- Recent studies show that Sox11 can be modified by phosphorylation, particularly at a specific site (S133) influenced by protein kinase A (PKA).
- Phosphorylation at S133 plays a significant role in dendrite development and gene activation in neurons, highlighting SOX11's importance in PKA-regulated neuronal development.
Article Synopsis
- - This study examined different tractography methods to identify cerebellar-thalamic fiber bundles important for deep brain stimulation (DBS) planning, focusing on the dentate-rubro-thalamic tract (DRTT) and the cerebello-thalamo-cortical (CTC) tract.
- - Six movement disorder patients underwent MRI scans with two sets of diffusion-weighted images, and both probabilistic and deterministic tractography techniques were used to analyze the DRTT and CTC, highlighting differences in tracking sensitivity and processing time.
- - Results indicated that probabilistic tracking reliably detected the DRTT across all brain hemispheres and additional fiber tracts, while deterministic tracking performed better for detecting the CTC, although
Some patients under thalamic deep brain stimulation (DBS) for essential tremor (ET) experience habituation of tremor reduction. The nucleus ventralis intermedius (Vim) is the current main target side for ET in DBS. However, the dentatorubrothalamic tract (DRTT) is considered the relevant structure to stimulate.
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- The study explores how cellular metabolism, especially mitochondrial function, plays a crucial role in the development of neurons from neural stem cells in the hippocampus, particularly focusing on the stage of rapidly dividing progenitor cells.
- Disruption of mitochondrial function due to loss of a specific transcription factor leads to age-related issues in neurogenesis, mimicking signs of aging in brain function.
- Enhancing mitochondrial function appears to counteract these age-related deficiencies, suggesting that targeting mitochondrial health could help improve neurogenesis in older adults.