Publications by authors named "K Stefic"
Background: Neutralizing antibodies targeting the SARS-CoV-2 Spike protein reduce COVID-19-related risk of hospitalization, particularly in high-risk individuals. The COCOPREV-R study aimed to evaluate and compare clinical outcomes in high-risk SARS-CoV-2 patients treated with dual monoclonal antibody therapies and to identify associated virological factors.
Methods: The COCOPREV-R study retrospectively collected real-world data from high-risk patients receiving Bamlanivimab/Etesevimab or Casirivimab/Imdevimab dual monoclonal antibody therapies (22 February 2021 to 15 June 2021).
Article Synopsis
- Surveillance of Transmitted Drug Resistance (TDR) is essential for understanding the changes in HIV trends, with a focus on multiple types of antiretroviral drugs and new treatments.
- A study involving 85 individuals diagnosed with primary HIV-1 infection (PHI) from 2020 to 2023 analyzed genetic sequences to identify TDR and its impact on drug resistance, revealing varying levels of resistance to several drug classes.
- The findings highlight the importance of monitoring TDR at the onset of HIV infection to improve treatment strategies and the effectiveness of pre-exposure prophylaxis (PrEP) with newer drug options.
Background And Objectives: In 2016, France allowed men who have sex with men (MSM) to donate blood if they had not had sex with men in the previous 12 months. In April 2020, this restriction was relaxed to 4 months due to the lack of negative impact observed on blood safety. This study assesses the impact of reducing this deferral period on epidemiological surveillance indicators.
View Article and Find Full Text PDFObjective: HIV Pre-Exposure Prophylaxis (PrEP) has been used in France since 2016. Its effectiveness is no longer to be demonstrated. However, follow-up and adherence remain the main pitfalls.
View Article and Find Full Text PDFArticle Synopsis
- Patients with X linked agammaglobulinemia and those receiving anti-CD20 monoclonal antibodies (mAbs) for immune-mediated inflammatory diseases (IMIDs) are at increased risk for severe enterovirus (EV) infections, particularly meningoencephalitis.
- A study collected data from nine original cases and 17 previously published cases, revealing a high occurrence of meningoencephalitis (81%) and a mortality rate of 27% among affected patients treated with multiple anti-CD20 mAbs.
- The findings suggest that clinicians should consider EV infections in IMID patients presenting unusual symptoms and recognize that anti-CD20 mAbs can impair B-cell responses to EV infections, potentially indicating