Publications by authors named "K Stauderman"
Article Synopsis
- Acute pancreatitis (AP) is a serious inflammatory condition with no specific treatments available; it's triggered by factors like elevated calcium levels and ATP depletion.
- A new drug, CM4620, currently in Phase 2b trials, shows promise as a CRAC channel inhibitor for AP but requires high concentrations for effectiveness, which could cause side effects.
- Combining lower doses of CM4620 with galactose, a natural carbohydrate, significantly enhances protective effects against cell damage and inflammation in AP models, suggesting a synergistic approach to treatment.
Article Synopsis
- * There are currently no targeted treatments for either RAP or early CP, making it important to explore the underlying cell interactions that lead to disease progression.
- * This study found that inhibiting Orai1, a key signaling mechanism linked to calcium overload in pancreatic cells, can halt the progression of RAP and early CP, suggesting that targeting Orai1 might help prevent severe stages of CP.
Article Synopsis
- Microglia play a crucial role in neuroinflammation related to neuropathic pain, but the specific molecular mechanisms regulating their activity, particularly through Orai1 channels, are not fully understood.
- Research showed that deleting Orai1 in microglia reduced calcium signaling and inflammatory cytokine production, leading to decreased microglial proliferation and less pain sensitivity in male mice after nerve injury.
- Interestingly, Orai1’s effects revealed sexual dimorphism, as the protective benefits seen in males were not observed in female mice, highlighting a potential difference in how neuroinflammation and pain are regulated by microglia across sexes.
T cell activation and function depend on Ca signals mediated by store-operated Ca entry (SOCE) through Ca release-activated Ca (CRAC) channels formed by ORAI1 proteins. We here investigated how SOCE controls T cell function in pulmonary inflammation during a T helper 1 (T1) cell-mediated response to influenza A virus (IAV) infection and T2 cell-mediated allergic airway inflammation. T cell-specific deletion of did not exacerbate pulmonary inflammation and viral burdens following IAV infection but protected mice from house dust mite-induced allergic airway inflammation.
View Article and Find Full Text PDFInflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the lamina propria (LP) of patients with ulcerative colitis (UC) and Crohn's disease (CD), we observed an enrichment of CD4 effector T cells producing IL-17A and TNF, CD8 T cells producing IFNγ, T regulatory (Treg) cells, and innate lymphoid cells (ILC). The function of these immune cells is regulated by store-operated Ca entry (SOCE), which results from the opening of Ca release-activated Ca (CRAC) channels formed by ORAI and STIM proteins.
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