Publications by authors named "K Stauch"
Neurodegenerative Tauopathies are a part of several neurological disorders and aging-related diseases including, but not limited to, Alzheimer's Disease, Frontotemporal Dementia with Parkinsonism, and Chronic Traumatic Encephalopathy. The major hallmarks present in these conditions include Tau pathology (composed of hyperphosphorylated Tau tangles) and synaptic loss. in vivo studies linking Tau pathology and mitochondrial alterations at the synapse, an avenue that could lead to synaptic loss, remain predominantly scarce.
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- - Parkinson's disease (PD) is primarily caused by the loss of dopamine-producing neurons in the brain, with mutations in the Pink1 and Parkin proteins linked to familial cases of PD.
- - Recent findings show that Pink1 and Parkin also play a role in how peripheral blood cells (PBMCs) manage energy metabolism, impacting immune cell populations by increasing CD4+ T cells while decreasing CD8+ T cells and B cells in rats.
- - The deficiency of Pink1/Parkin contributes to higher platelet counts and increased aggregation of platelets with lymphocytes, which raises the risk of thrombosis, indicating that targeting these proteins could lead to new therapeutic strategies for PD.
Article Synopsis
- Traumatic brain injury (TBI) is a major cause of injury-related death and disability in the U.S., and managing neuroinflammation early is crucial for treatment.
- Pioglitazone, a drug that may reduce inflammation after TBI, shows potential but also has unknown long-term effects that can worsen brain conditions.
- Research in mice indicates that acute/subacute treatment with pioglitazone leads to negative outcomes, including brain damage and behavior changes, highlighting the need for sex-based considerations and further investigation before clinical use for TBI.
Honey bees are a commonly used species for alcohol research due to their genome being fully sequenced, their behavioral changes following consumption, and their preference for alcohol. The purpose of this article is to provide a preliminary examination of the genetic expression of heat shock protein 70 (HSP70) and big potassium ion channel protein (BKP) in honey bees following the consumption of either 0%, 2.5%, 5%, or 10% ethanol (EtOH) solutions.
View Article and Find Full Text PDFMitochondrial quality control is essential in mitochondrial function. To examine the importance of Parkin-dependent mechanisms in mitochondrial quality control, we assessed the impact of modulating Parkin on proteome flux and mitochondrial function in a context of reduced mtDNA fidelity. To accomplish this, we crossed either the Parkin knockout mouse or ParkinW402A knock-in mouse lines to the Polg mitochondrial mutator line to generate homozygous double mutants.
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