Five steps in performing machine learning for binary outcomes.

Background: The use of machine learning (ML) in cardiovascular and thoracic surgery is evolving rapidly. Maximizing the capabilities of ML can help improve patient risk stratification and clinical decision making, improve accuracy of predictions, and improve resource utilization in cardiac surgery. The many nuances and intricacies of ML modeling need to be understood to appropriately implement these technologies in the clinical research setting.

Data from the experiment of dynamic moisture transport in spruce wood under cyclic step-changes in relative humidity 72-95.

The interaction of wood and moisture has to be considered in many industrial sectors. Wood is highly hygroscopic material while the absorbed moisture affects all its technical properties. One of them is a moisture permeability which is further affected by the sorption hysteresis and also differs in the three wood anatomical directions - radial, tangential, and axial.

Improving Patient Safety Through Proper Ordering and Administration of Andexanet Alfa.

Objective: To evaluate prescribing practices for the anti-Xa reversal agent, andexanet alfa, to identify challenges in ordering and administering this medication, and to offer recommendations to improve patient safety.

Patients And Methods: This retrospective study reviewed all adult patients treated with andexanet alfa (AA) at a single institution between January 1, 2018, and March 31, 2020. We identified ordering and administration benchmarks based on recommendations from previous clinical trials on AA.

Multidisciplinary Velopharyngeal Dysfunction Evaluation Helps Detect Non-classic Cases of 22q11.2 Deletion.

Objective: To explore the role of multidisciplinary velopharyngeal dysfunction (VPD) assessment in diagnosing 22q11.2 deletion syndrome (22q) in children.

Design: Retrospective cohort study.

Suprazygomatic Maxillary Nerve Block in Palatoplasty: A Retrospective Cohort Study of Perioperative Outcomes in Syndromic and Non-Syndromic Children.

Objective: This study compares the impact of surgical site infiltration of local anesthesia alone to surgical site infiltration plus suprazygomatic maxillary nerve block (SMB) in non-syndromic and syndromic children undergoing primary palatoplasty.

Design: Retrospective cohort study of intra- and post-operative outcomes and opioid utilization in children undergoing palatoplasty by a single surgeon.

Setting: Urban, academic, tertiary care children's hospital.