SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF.

Sirtuin 7 (SIRT7) is a member of the mammalian family of nicotinamide adenine dinucleotide (NAD)-dependent histone/protein deacetylases, known as sirtuins. It acts as a potent oncogene in numerous malignancies, but the molecular mechanisms employed by SIRT7 to sustain lung cancer progression remain largely uncharacterized. We demonstrate that SIRT7 exerts oncogenic functions in lung cancer cells by destabilizing the tumor suppressor alternative reading frame (ARF).

Effective connectivity of working memory performance: a DCM study of MEG data.

Visual working memory (WM) engages several nodes of a large-scale network that includes frontal, parietal, and visual regions; however, little is understood about how these regions interact to support WM behavior. In particular, it is unclear whether network dynamics during WM maintenance primarily represent feedforward or feedback connections. This question has important implications for current debates about the relative roles of frontoparietal and visual regions in WM maintenance.

Phenomenology of transition to quantum turbulence in flows of superfluid helium.

Transition from laminar to turbulent states of classical viscous fluids is complex and incompletely understood. Transition to quantum turbulence (QT), by which we mean the turbulent motion of quantum fluids such as helium II, whose physical properties depend on quantum physics in some crucial respects, is naturally more complex. This increased complexity arises from superfluidity, quantization of circulation, and, at finite temperatures below the critical, the two-fluid behavior.

Saturation and Multifractality of Lagrangian and Eulerian Scaling Exponents in Three-Dimensional Turbulence.

Inertial-range scaling exponents for both Lagrangian and Eulerian structure functions are obtained from direct numerical simulations of isotropic turbulence in triply periodic domains at Taylor-scale Reynolds number up to 1300. We reaffirm that transverse Eulerian scaling exponents saturate at ≈2.1 for moment orders p≥10, significantly differing from the longitudinal exponents (which are predicted to saturate at ≈7.