Publications by authors named "K Spaniol"
Article Synopsis
- The study investigates the long-term clinical outcomes (up to 10 years) of Descemet Membrane Endothelial Keratoplasty (DMEK) and Triple-DMEK procedures in patients with conditions like Fuchs endothelial dystrophy and pseudophakic bullous keratopathy.
- A total of 54 eyes were followed for at least 5 years, revealing significant improvements in best-corrected visual acuity post-surgery, though endothelial cell density decreased over time, independent of visual acuity.
- Findings suggest that while endothelial cell density declines, patients maintain good vision for a decade post-surgery, with stable corneal thickness and relatively low rates of graft failure and complications.
Article Synopsis
- Sustainable treatment for aqueous deficient dry eye (ADDE) is lacking, necessitating new strategies like tissue-specific hydrogels that mimic the extracellular matrix to support cell function.
- Researchers developed a decellularized lacrimal gland hydrogel (dLG-HG) that maintains the necessary biochemical properties, showing improved cell proliferation and secretion capabilities compared to standard culture substrates like Matrigel and collagen type-I.
- While dLG-HG promotes vital cell interactions and functions, its rapid biodegradation poses challenges for long-term cultivation, indicating a need for further research to slow this process.
Prcis: A main safety concern associated with new glaucoma implants is corneal endothelial cell loss, which could even be observed in already established procedures.
Purpose: The purpose of this study was to evaluate the efficacy and corneal safety, especially corneal endothelial cell loss (ECL), after Preserflo MicroShunt implantation.
Methods: A monocentric, prospective clinical observational study of patients with a follow-up of at least 12 months who underwent Preserflo MicroShunt implantation at the Department of Ophthalmology, University Hospital of Düsseldorf, Germany, between January 2020 and October 2021.
Influence of Storage Conditions on Decellularized Porcine Conjunctiva.
Bioengineering (Basel)
March 2023
Porcine decellularized conjunctiva (PDC) represents a promising alternative source for conjunctival reconstruction. Methods of its re-epithelialization in vitro with primary human conjunctival epithelial cells (HCEC) have already been established. However, a long-term storage method is required for a simplified clinical use of PDC.
View Article and Find Full Text PDFBackground: In recent years, an increasing number of surgical microscopes fitted with an OCT module (intraoperative OCT, iOCT) have become available, providing high-resolution images of the surgical site in real time. While a 2018 survey at our hospital showed that iOCT delivered an additional intraoperative benefit in only 2.4% of all operations, considering that the manufacturer had since revised the hardware and software, we conducted a second user evaluation of this technology.
View Article and Find Full Text PDF