Publications by authors named "K Soukup"
Brain metastasis (BrM) is a common malignancy, predominantly originating from lung, melanoma, and breast cancers. The vasculature is a key component of the BrM tumor microenvironment with critical roles in regulating metastatic seeding and progression. However, the heterogeneity of the major BrM vascular components, namely endothelial and mural cells, is still poorly understood.
View Article and Find Full Text PDFArticle Synopsis
- Melanoma often spreads to the brain, making it crucial to understand how melanoma cells pass through the blood-brain barrier (BBB) to prevent brain metastases.
- Using primary mouse brain microvascular endothelial cells (pMBMECs), researchers studied how melanoma cells interact with and disrupt the BBB, noting that inhibiting certain proteases can help restore this barrier.
- The study also involved a new melanoma cell line and experiments with PECAM-1-deficient mice, showing that compromised barrier properties lead to increased melanoma cell movement across the BBB, highlighting the importance of maintaining BBB integrity to reduce brain metastasis.
Article Synopsis
- * A study looked closely at neutrophils in tumor tissues from patients with glioma (a type of brain cancer) and brain metastasis (cancer that has spread to the brain) and compared them to those in blood.
- * The researchers found that neutrophils in brain tumors are different from those in blood; they live longer and can help tumors grow by suppressing the immune response and causing inflammation.
The immune-specialized environment of the healthy brain is tightly regulated to prevent excessive neuroinflammation. However, after cancer development, a tissue-specific conflict between brain-preserving immune suppression and tumor-directed immune activation may ensue. To interrogate potential roles of T cells in this process, we profiled these cells from individuals with primary or metastatic brain cancers via integrated analyses on the single-cell and bulk population levels.
View Article and Find Full Text PDFStructured catalytic membranes with high porosity and a low pressure drop are particularly suitable for industrial processes carried out at high space velocities. One of these processes is the catalytic total oxidation of volatile organic compounds, which is an economically feasible and environmentally friendly way of emission abatement. Noble metal catalysts are typically preferred due to high activity and stability.
View Article and Find Full Text PDF