Publications by authors named "K Sonomoto"
Objective: To elucidate the association between the changes in intracellular metabolism in the early stage of B cell activation and systemic lupus erythematosus (SLE) pathogenesis.
Methods: CD19 or CD19CD27 (naïve) cells from the peripheral blood of healthy controls and lupus patients were cultured under different stimuli. The changes in intracellular metabolism and signalling pathways in these cells were evaluated.
Article Synopsis
- The study investigates the safety and effectiveness of various DMARDs, including methotrexate (MTX), tofacitinib, tumor necrosis factor inhibitors (TNFi), and non-TNFi biologic DMARDs, in patients with rheumatoid arthritis (RA) using data from the CorEvitas RA Japan registry.
- Safety outcomes measured include major cardiovascular events, serious infections, herpes zoster, and malignancies, while effectiveness was measured using the Clinical Disease Activity Index (CDAI).
- Findings show that MTX and TNFi had lower rates of adverse cardiovascular events compared to tofacitinib and non-TNFi, but tofacitinib demonstrated superior effectiveness in improving CDAI scores at 6 months
Article Synopsis
- - The study examined factors influencing the improvement of health assessment questionnaire-disability index (HAQ-DI) and pain scores in rheumatoid arthritis (RA) patients who achieved low disease activity (LDA) after treatment with biological and targeted-synthetic DMARDs.
- - Data from the FIRST registry highlighted that seropositivity and the use of JAK inhibitors were positively linked to both HAQ-DI normalization and pain score reduction, while older age, history of treatment failures, and higher baseline HAQ-DI were associated with poorer outcomes.
- - The findings suggest that certain treatments may be more effective early on in managing RA, indicating avenues for preventing the condition from becoming difficult to treat.
Objectives: The tuning effects of JAK/TYK2 inhibitors on the imbalance between T follicular helper (Tfh) and T regulatory (Treg) cells, related to systemic lupus erythematosus (SLE) pathogenesis, were investigated using human peripheral blood samples.
Methods: Peripheral blood mononuclear cells from untreated patients with SLE and healthy controls were analysed. Tfh1 cells were identified in nephritis tissue, and the effect of Tfh1 cells on B-cell differentiation was examined by coculturing naïve B cells with Tfh1 cells.
Objective: To investigate the early detection of pulmonary non-tuberculous mycobacterial (PNTM) disease by CT before the initiation of molecular-targeted therapeutic drugs in patients with rheumatoid arthritis (RA) and the efficacy and safety of combined treatment with antibiotics.
Methods: Patients with RA underwent chest CT before the introduction of molecular-targeted therapies in the Further Improvement of Rheumatoid arthritis Treatment registry. The primary endpoint was the number of patients who were detected by CT as having PNTM disease, complicating RA.