Publications by authors named "K Sokolov"
This study presents a statistical analysis of how gold nanoparticle (GNP) size and polyethylene glycol (PEG) coating molecular weight (MW) affect the circulation of nanoparticles in blood. We showed a non-linear relationship with interaction between GNP size and PEG MW. The findings revealed a threshold effect, and recommendations for GNP coating are discussed.
View Article and Find Full Text PDFPurpose: Clinical adoption of NK cell immunotherapy is underway for medulloblastoma and osteosarcoma, however there is currently little feedback on cell fate after administration. We propose magnetic particle imaging (MPI) may have applications for the quantitative detection of NK cells.
Procedures: Human-derived NK-92 cells were labeled by co-incubation with iron oxide nanoparticles (VivoTrax™) for 24 h then excess nanoparticles were washed with centrifugation.
Article Synopsis
- bRT before CAR T-cell therapy for LBCL is gaining traction, but its impact on treatment outcomes is unclear.
- A study analyzed 23 LBCL patients who underwent bRT followed by CAR T-cell therapy, focusing on various PET scan metrics to measure tumor response.
- Results revealed that significant decreases in SUV and MTV during bRT were linked to better progression-free survival, freedom from distant progression, and local control.
- The findings suggest that greater cytoreduction via bRT may enhance the effectiveness of subsequent CAR T-cell therapy in treating large B-cell lymphoma.
Article Synopsis
- Imaging is essential in cancer care for detection, diagnosis, and monitoring, with photoacoustic imaging (PAI) gaining attention due to its high sensitivity and tissue penetration.
- A novel approach involves encapsulating indocyanine green J (ICGJ) in biodegradable polymersomes to enhance PAI, achieving a small hydrodynamic diameter for better in vivo applications and targeted delivery through conjugation with EGFR-targeting antibodies.
- The polymersome-labeled breast cancer cells can be detected via PAI, even in turbid conditions, demonstrating the method's potential for clinical applications like tumor margin detection and lymph node evaluation.
Nanoparticle delivery to solid tumors is a prime challenge in nanomedicine. Here, we approach this challenge through the lens of biogeochemistry, the field that studies the flow of chemical elements within ecosystems as manipulated by living cellular organisms and their environments. We leverage biogeochemistry concepts related to gold cycling against pancreatic cancer, considering mammalian organisms as drivers for gold nanoparticle biosynthesis.
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