Publications by authors named "K Sofia Appelberg"
Article Synopsis
- A budget impact analysis was conducted to compare the costs of current treatment strategies with a new approach for population screening of atrial fibrillation (AF) in 75-year-olds across eight European countries.
- The analysis showed that while AF screening leads to increased initial costs due to higher drug and screening expenses, it ultimately results in savings from reduced stroke-related costs.
- The net budget impact of implementing AF screening varied by country, ranging from €10 in Ireland to €122 in the Netherlands, demonstrating the overall financial benefit of the screening despite the upfront costs.
Objective: To evaluate the long-term costs and health effects of the Swedish newborn screening program for classic phenylketonuria (PKU) alone and in combination with congenital hypothyroidism compared with no screening.
Study Design: A decision-analytic model was developed to estimate and compare the long-term (80 years) costs and health effects of newborn screening for PKU and congenital hypothyroidism. Data were obtained from the literature and translated to Swedish conditions.
Formalin-fixed paraffin embedding (FFPE) is the most widespread long-term tissue preservation approach. Here, we report a procedure to perform genome-wide spatial analysis of mRNA in FFPE-fixed tissue sections, using well-established, commercially available methods for imaging and spatial barcoding using slides spotted with barcoded oligo(dT) probes to capture the 3' end of mRNA molecules in tissue sections. We applied this method for expression profiling and cell type mapping in coronal sections from the mouse brain to demonstrate the method's capability to delineate anatomical regions from a molecular perspective.
View Article and Find Full Text PDFHazara virus (HAZV) belongs to the family and is included in the same serogroup of the Crimean-Congo hemorrhagic fever virus (CCHFV). CCHFV is the most widespread tick-borne arbovirus. It is responsible for a serious hemorrhagic disease, for which specific and effective treatment and preventive systems are missing.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (COVID-19) has caused a global health emergency. A key feature of COVID-19 is dysregulated interferon-response. Type-I interferon (IFN-I) is one of the earliest antiviral innate immune responses following viral infection and plays a significant role in the pathogenesis of SARS-CoV-2.
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