Publications by authors named "K Sobotkova"

The recent return of samples from asteroid 162173 Ryugu provides a first insight into early Solar System prebiotic evolution from known planetary bodies. Ryugu's samples are CI chondrite-like, rich in water and organic material, and primarily composed of phyllosilicate. This phyllosilicate surrounds micron to submicron macromolecular organic particles known as insoluble organic matter.

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Background: Retraction pocket (RP) of the tympanic membrane (TM) is a common pathology in children that can cause ossicular chain erosion, cholesteatoma formation, and potentially life-threatening complications of cholesteatoma. This study assessed the functional and anatomical results of cartilage grafting in children with severe RP of the TM.

Methods: This was a retrospective review of 212 children from a tertiary referral center.

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Fourth branchial cleft anomalies are rare head and neck congenital lesions seen in children. They present as a neck inflammatory mass and arise essentially on the left side of the neck. We report the case of a 7-month-old female with a mass of the neck associated with respiratory distress.

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Studies in animal models and humans suggest that intentional exposure to helminths or helminth-derived products may hold promise for treating chronic inflammatory-associated diseases (CIADs). Although the mechanisms underlying 'helminth therapy' are being evaluated, little attention has been paid to the actual organisms in use. Here we examine the notion that, because of the complexity of biological symbiosis, intact helminths rather than helminth-derived products are likely to prove more useful for clinical purposes.

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Article Synopsis
  • The tapeworm Hymenolepis diminuta serves as a model to study how it affects the mammalian immune system, particularly its potential therapeutic benefits for immune-mediated inflammatory diseases (IMIDs).
  • In mouse studies, H. diminuta has shown protective effects against inflammatory colitis by triggering a strong type 2 immune response aimed at expelling the immature worm, whereas rats, its definitive hosts, develop a milder immune response without significant colitis relief.
  • Research indicates that while immature H. diminuta can activate a type 2 response in rats, only mature H. diminuta significantly reduces inflammation and clinical symptoms of colitis, suggesting different life cycle stages of the worm play distinct roles in immune interactions.
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