Publications by authors named "K Sinclair"
Investigating the Reliability of Shore Hardness in the Design of Procedural Task Trainers.
Bioengineering (Basel)
January 2025
The haptic fidelity of biomimetic materials used in the design of procedural task trainers is of growing interest to the medical community. Shore hardness has been proposed as a method for assessing tissue biomechanics and replicating the results as a way to increase the fidelity of biomimetics to tissues. However, there is limited research on the reliability of human tissue measurements using Shore scales.
View Article and Find Full Text PDFBackground: Despite new modern surgical techniques, no short-term functional differences have been demonstrated between operative and non-operative treatment for acute acromio-clavicular (AC) dislocations Rockwood III-V. Few studies describe the long-term clinical and radiological results of these lesions. We aim to compare the one- and ten-year outcome of patients either treated non-operatively or with hook plate fixation for Rockwood III AC lesions.
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- Chronic exposure to environmental chemicals (ECs) affects human health, leading to non-communicable diseases, and studying these effects in real-world conditions requires animal models that mimic such exposure.
- Research using sheep exposed to biosolids found metabolic changes in offspring, including altered liver gene expression and sex-specific effects on metabolism.
- The study identified significant differences in gene expression and liver function, particularly in male lambs, suggesting that prenatal exposure to low-dose mixtures of ECs disrupts normal metabolic processes and sexual dimorphism in liver function.
The developmental integrity and wellbeing of offspring are influenced by events that occur in utero, particularly around the time of conception. While extraneous factors such as environmental temperature and exposure to environmental chemicals can each have a bearing on these events, the epigenetic mechanisms that direct cellular differentiation during early development in ruminants are best described for studies which have investigated the effects of parental nutrition or pregnancy outcomes following assisted reproduction. In this article the case is made that the genetic constitution of an individual directs epigenetic responses to environmental stimuli, and consideration in this regard is also given to the origins of sexual dimorphism and mechanisms of germline intergenerational inheritance.
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- The study focuses on how the intake of polyunsaturated fatty acids (PUFAs) during the periconceptional period affects embryonic development, particularly embryonic volume (EV) and head volume (HV) in pregnant women.* -
- Findings reveal that many women have low omega-3 intake, and while higher PUFA intake is linked to a smaller HV/EV ratio, it does not correlate with individual EV or HV growth measures.* -
- The research highlights a significant omega-3 deficiency in pregnant women and emphasizes the need for better awareness of PUFA intake to mitigate risks of negative pregnancy outcomes.*