Publications by authors named "K Sims"
Article Synopsis
- The World Health Organization and CDC have set goals for eliminating hepatitis C virus (HCV) by 2030, but the U.S. is falling short due to various barriers such as lack of awareness, misinformation, and treatment accessibility issues.
- The objective of the study was to create a high-quality educational app aimed at improving knowledge about HCV testing and treatment among patients and healthcare workers, featuring five interactive learning modules.
- The app was tested with 561 users, with over a third engaging with the training modules, where many spent significant time learning about HCV, indicating an interest in improving knowledge on the disease and its treatment process.
HBV capsid assembly modulators (CAMs) target the core protein and inhibit pregenomic RNA encapsidation and viral replication. HBV CAMs also interfere with cccDNA formation during de novo infection, which in turn suppresses transcription and production of HBV antigens. In this report, we describe the antiviral activities of AB-836, a potent and highly selective HBV CAM.
View Article and Find Full Text PDFBackground And Aims: Colorectal cancer (CRC) polygenic risk scores (PRS) may help personalize CRC prevention strategies. We investigated whether an existing PRS was associated with advanced neoplasia (AN) in a population undergoing screening and follow-up colonoscopy.
Methods: We evaluated 10-year outcomes in the Cooperative Studies Program #380 screening colonoscopy cohort, which includes a biorepository of selected individuals with baseline AN (defined as CRC or adenoma ≥10 mm or villous histology, or high-grade dysplasia) and matched individuals without AN.
Measuring age-specific, contextual exposures is crucial for lifecourse epidemiology research. Longitudinal residential data offers a "golden ticket" to cumulative exposure metrics and can enhance our understanding of health disparities. Residential history can be linked to myriad spatiotemporal databases to characterize environmental, socioeconomic, and policy contexts that a person experienced throughout life.
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