Publications by authors named "K Simitchiev"
In this study, the best corrected visual acuity (BCVA) and refraction in preterm-born infants in South-Eastern Bulgaria after 12 years of treatment for type 1 prethreshold retinopathy of prematurity were presented, and the outcomes of laser treatment and cryotherapy were compared.
View Article and Find Full Text PDFThe current research aims to develop a new analytical method applying a dispersive liquid-liquid microextraction (DLLME) assisted by vortex and using an environmentally friendly extractant for the preconcentration of organochlorine and organophosphorus pesticides followed by gas chromatography-tandem mass spectrometry (GC-MS/MS) analysis. The extractant (i.e.
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- The study aimed to categorize subgroups of patients with primary osteoarthritis of the hip joint based on their imaging and lab results, disease progression, and treatment responses.
- Researchers reanalyzed data from two double-blind, randomized clinical trials examining the effects of various treatments, including corticosteroids, hyaluronic acid, and bisphosphonates, over an 8-year period involving 700 patients.
- Multiple clinical, laboratory, radiological, and therapeutic response indicators were assessed and analyzed using hierarchical agglomerative clustering to identify distinct patient profiles or endophenotypes for better-targeted therapies.
Тhe poor prognosis of patients initially diagnosed at an advanced stage of colorectal cancer (CRC) and the heterogeneity within the same tumor stage define the need for additional predictive biomarkers. Tumor buds are proposed as a poor prognostic factor for CRC, however, they are still not implemented into routine pathology reporting. In turn, the chitinase-3-like protein 1 (CHI3L1) also known as YKL-40, is regarded as a candidate circulating biomarker and therapeutic target in CRC.
View Article and Find Full Text PDFCloud point extraction is an environmentally benign and simple separation/concentration procedure that can be regarded as an alternative to classical liquid-liquid extraction. In the current work, it was studied the compatibility of cloud point extraction followed by back-extraction in low volume of organic solvent with gas chromatography-mass spectrometry (GC-MS and GC-MS/MS). Triton X-100 was preferred than Triton X-114 as a surfactant to produce the clouding phenomenon and hexane or isooctane was found to be appropriate organic solvents which can be used at the back-extraction step.
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