Publications by authors named "K Sigaloff"
Liver abscesses secondary to a non-O1/non-O139 Vibrio cholerae bacteremia acquired in a non-coastal area: a case report.
Ann Clin Microbiol Antimicrob
December 2024
Non-O1/non-O139 Vibrio cholerae (NOVC) strains are a distinct group of Vibrio cholerae that do not cause epidemic cholera. NOVC infections usually cause mild forms of gastroenteritis, and rarely severe (extra)intestinal infections, mostly affecting immunocompromised patients. Here, we describe the clinical course of a patient with NOVC bacteremia causing multiple liver abscesses, after drinking from a freshwater well in a non-coastal area.
View Article and Find Full Text PDF"Doctor, would it surprise you if there were prescribing errors in this patient's medication?" Identifying eligible patients for in-hospital pharmacotherapeutic stewardship: A matched case-control study.
Br J Clin Pharmacol
October 2024
Background: Evaluating a patient's medication list is critical to reduce prescribing errors (PEs), but is a labour- and time-intensive process. Identification of patients at risk of PEs could improve the allocation of scarce time and resources, but currently available prediction tools are not effective.
Objective: To investigate whether ward doctors can identify patients at risk of PEs.
Article Synopsis
- An umbrella review was conducted to evaluate existing evidence on optimal antibiotic treatment durations for various respiratory tract infections, focusing on whether shorter courses are as effective as longer ones.
- The review included systematic reviews of conditions like community-acquired pneumonia and acute sinusitis, assessing factors like clinical outcomes and the quality of the studies using established criteria.
- Findings indicated that most systematic reviews were of low quality, but there was some support for a 5-day treatment duration for community-acquired pneumonia and acute exacerbation of chronic obstructive pulmonary disease; however, reliable evidence for other conditions and shorter durations is lacking.
Article Synopsis
- The study aimed to identify risk factors for acute kidney injury (AKI) and assess its impact on mortality in patients with Staphylococcus aureus bacteraemia (SAB), considering variables like recurrent AKI episodes and competing risks.
- A total of 453 patients were analyzed, revealing that 43% experienced AKI episodes, with age, comorbidity, septic shock, persistent bacteraemia, and vancomycin therapy linked to an increased AKI risk.
- The findings highlighted that AKI significantly raises the risk of 90-day mortality in SAB patients, indicating a worse clinical outcome than previously understood, especially in those treated with vancomycin.
Background: Avoiding excessive antibiotic treatment duration is a fundamental goal in antimicrobial stewardship. Manual collection of data is a time-consuming process, but a semi-automated approach for data extraction has been shown feasible for community-acquired infections (CAI). Extraction of data however may be more challenging in hospital-acquired infections (HAI).
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