Interference of psychotropic drugs with the injuring action of ethanol on gastric mucosal barrier.

The aim of this study was to establish whether some psychotropic drugs, applied to patients under influence of alcohol, may potentiate its damaging action on gastric mucosal barrier. A sensitive index of such damage is a decline of the potential difference (PD) across the stomach wall. The experiments were carried out on Wistar rats of either sex, anesthetized with urethane-chloralose.

[Changes in electrical potentials of gastric mucosa during various types of experimental hypoxia].

In experiments performed on anaesthetized male and female Wistar rats the effects of different types of hypoxia on the electrical potential difference (PD) between the inner and the outer sides of the gastric wall were examined. The PD was determined by mean of the Digital Multimeter VC-10T, Unitra, and the calomel electrodes connected with the KCl-agar bridges. There were four series of experiments carried out in which hypoxia was produced by: I--low atmospheric pressure (hypobaric hypoxia) corresponding with the altitudes of 2500, 5500, 8500 and 10,500 m above sea level, II--1 min.