Publications by authors named "K Sieber"
Olfaction is essential for complex social behavior in insects. To discriminate complex social cues, ants evolved an expanded number of () genes. Mutations in the obligate odorant co-receptor gene lead to the loss of ~80% of the antennal lobe glomeruli in the jumping ant .
View Article and Find Full Text PDFPopulation affinity estimation is an important step in the identification of unknown individuals. To ensure accurate results, validation studies of newly developed methods must be performed using different target populations and skeletal elements. This research aimed to determine the accuracy and reliability of population affinity estimation on a modern Spanish sample using two online software applications.
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- The study investigates the genetic factors contributing to the decline in estimated glomerular filtration rate (eGFR), a key indicator of kidney function, by analyzing data from 62 longitudinal studies involving over 343,000 participants.
- Twelve significant genetic variants related to eGFR decline were identified, with most showing interaction effects based on age, which highlights how genetic influences on kidney function change as individuals get older.
- The findings emphasize that individuals with certain genetic profiles face higher risks for kidney failure and acute kidney injury, providing valuable insights that could aid in drug development and strategies for managing kidney health.
Article Synopsis
- Reduced glomerular filtration rate (GFR) is a precursor to kidney failure, influenced by factors like genetics and diabetes (DM), but the interaction between these factors is not well understood.
- A large-scale genome-wide association study (GWAS) analyzed eGFR across almost 1.5 million individuals, revealing distinct genetic loci that differ between those with and without diabetes.
- The findings identified potential new targets for drug development aimed at protecting kidney function, highlighting that many drug interventions could be effective for both diabetic and non-diabetic populations.
Eusocial insects, such as bees, ants, and wasps of the Hymenoptera and termites of the Blattodea, are able to generate remarkable diversity in morphology and behavior despite being genetically uniform within a colony. Most eusocial insect species display caste structures in which reproductive ability is possessed by a single or a few queens while all other colony members act as workers. However, in some species, caste structure is somewhat plastic, and individuals may switch from one caste or behavioral phenotype to another in response to certain environmental cues.
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