Publications by authors named "K Shono"
Background Aims: Allogeneic hematopoietic stem cell transplantation (HSCT) improves outcomes for myelodysplastic syndrome (MDS) patients, but relapse rates remain high, and postrelapse treatment options are limited. Therefore, this study aimed to identify the factors contributing to the response to donor lymphocyte infusion (DLI) in relapsed MDS patients post-HSCT.
Methods: This study included 107 patients with relapsed and DLI-treated MDS who underwent their first HSCT between 2002 and 2022 and were registered in the Transplant Registry Unified Program.
A prospective multicenter observational study of organ response was conducted in patients with chronic GVHD diagnosed by the NIH criteria. When response was assessed at 12 months (12 M) in 118 patients, 74.6% were classified as responders and 25.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates the activity and sleep patterns of patients with postherpetic neuralgia (PHN) using actigraphy, which is a tool that measures movement similar to a wristwatch.
- Researchers found that while subjective reports of pain and sleep issues were well correlated, actigraphy results showed no objective link between activity levels and these subjective experiences.
- The authors suggest that the mismatch between subjective and objective data could be due to specific characteristics of PHN, limitations of actigraphy in tracking sedentary lifestyles, or a phenomenon called activity misperception, where individuals may misjudge their own activity levels.
Clinically significant cytomegalovirus infection (csCMVi) is frequently observed after allogeneic hematopoietic stem cell transplantation (HSCT) and prophylaxis with letermovir is commonly adopted. However, the clinical benefit of letermovir prophylaxis according to graft sources has not been sufficiently elucidated. We retrospectively analyzed 2194 recipients of HSCT who were CMV-seropositive (236 with letermovir prophylaxis and 1958 without prophylaxis against CMV).
View Article and Find Full Text PDFMalignant Phyllodes Tumor in a Pubertal Girl: A Report of a Case.
J Pediatr Adolesc Gynecol
February 2024
Background: Malignant phyllodes tumor (MPT) is a rare breast disease that is extremely rare in children. A few cases of pediatric malignant phyllodes tumors have been reported, including some with a poor prognosis.
Case: A 14-year-old girl presented with a growing lump on her right breast.