Oral Frailty and Its Relationship with Physical Frailty in Older Adults: A Longitudinal Study Using the Oral Frailty Five-Item Checklist.

Background/objectives: Oral frailty, first identified in Japan in 2014, refers to a state between healthy oral function and severe decline, marked by minor issues, such as tooth loss and chewing difficulties. The oral frailty five-item checklist (OF-5) enables non-dental professionals to evaluate oral frailty using five key indicators: remaining teeth count, chewing difficulties, swallowing difficulties, dry mouth, and articulatory oral skills. Limited studies exist.

Effects of the shortened dental arch on oral function in older adults: A prospective cohort study.

Statement Of The Problem: Previous longitudinal studies have found that patients with shortened dental arches (SDA) have a higher risk of long-term tooth loss than complete dental arch (CDA). However, the difference between SDA and CDA concerning oral function has yet to be demonstrated.

Purpose: We aimed to clarify the influence of molar occlusal support on oral function in SDA and CDA participants cross-sectionally and longitudinally.

STIL Overexpression Is Associated with Chromosomal Numerical Abnormalities in Non-Small-Cell Lung Carcinoma Through Centrosome Amplification.

STIL is a regulatory protein essential for centriole biogenesis, and its dysregulation has been implicated in various diseases, including malignancies. However, its role in non-small-cell lung carcinoma (NSCLC) remains unclear. In this study, we examined STIL expression and its potential association with chromosomal numerical abnormalities (CNAs) in NSCLC using The Cancer Genome Atlas (TCGA) dataset, immunohistochemical analysis, and in vitro experiments with NSCLC cell lines designed to overexpress STIL.

Prophylactic Clip Closure in Preventing Delayed Bleeding After Colorectal Endoscopic Submucosal Dissection on anticoagulants: A multicenter retrospective cohort study in Japan.

Background And Study Aims: Prophylactic clip closure after colorectal endoscopic submucosal dissection (ESD) among patients on anticoagulants is of uncertain effectiveness in reducing delayed bleeding (DB) risk. We aimed to assess the effect of prophylactic clip closure in preventing DB after colorectal ESD among patients on anticoagulants.

Patients And Methods: We used the ABCD-J study database, a large-scale multicenter study analyzing DB among 34,455 colorectal ESD cases from 47 Japanese institutions.

Association between frailty and subjective and objective sleep indicators in Japanese community-dwelling older adults.

Studies have linked frailty to sleep duration and/or quality using questionnaire-based subjective sleep assessments. This study clarified the relationship between frailty status and subjective and objective sleep indicators among community-dwelling older adults in a rural Japanese area. This cross-sectional cohort study analyzed the data of older adult participants in the FESTA Study, assessing subjective and objective sleep indicators using the Pittsburgh Sleep Quality Index (PSQI) and an actigraph, respectively.