Publications by authors named "K Shikata"
Article Synopsis
- CKD public education programs in Okayama Prefecture have been running since 2007, aiming to improve awareness and understanding of chronic kidney disease (CKD).
- A study conducted from 2015 to 2023 showed that overall awareness of CKD increased, particularly among the elderly, but remains low among younger individuals, with the term "chronic kidney disease" being more recognized than "CKD."
- The internet has emerged as a key source of information about CKD for younger people, highlighting the need for continued public education with clear communication tailored to the demographic audience to enhance understanding and awareness.*
Article Synopsis
- The CANPIONE study aimed to evaluate the effectiveness of canagliflozin, an SGLT2 inhibitor, in slowing the progression of chronic kidney disease (CKD) in participants with early-stage CKD and type 2 diabetes.
- In a trial involving 98 participants, those taking canagliflozin showed a significant reduction in urinary albumin levels and a slower decline in their estimated glomerular filtration rate (eGFR) compared to those receiving standard treatment.
- The study suggests that monitoring individual changes in eGFR slope could be a promising method for assessing the kidney-protective effects of new treatments in early CKD.
Cholesterol (Chol) plays a crucial role in shaping the intricate physicochemical attributes of biomembranes, exerting a considerable influence on water molecules proximal to the membrane interface. In this study, we conducted molecular dynamics simulations on the bilayers of two lipid species, dipalmitoylphosphatidylcholine (DPPC) and palmitoyl sphingomyelin; they are distinct with respect to the structures of the hydrogen-bond (H-bond) acceptors. Our investigation focuses on the dynamic properties and H-bonds of water molecules in the lipid-membrane systems, with a particular emphasis on the influence of Chol at varying temperatures.
View Article and Find Full Text PDFIntroduction: ACE cleaves angiotensin I (Ang I) to angiotensin II (Ang II) inducing vasoconstriction via Ang II type 1 (AT1) receptor, while ACE2 cleaves Ang II to Ang (1-7) causing vasodilatation by acting on the Mas receptor. In diabetic kidney disease (DKD), it is still unclear whether plasma or urine ACE2 levels predict renal outcomes or not.
Research Design And Methods: Among 777 participants with diabetes enrolled in the Urinary biomarker for Continuous And Rapid progression of diabetic nEphropathy study, the 296 patients followed up for 9 years were investigated.
Post-gastrectomy syndrome (PGS) and body weight loss (BWL) decrease quality of life (QOL) and survival of the patient undergoing gastrectomy. We have introduced perioperative and post-discharge continuous nutritional counseling (CNC) to prevent BWL and improve QOL after gastrectomy. In the present study, we evaluated the effect of CNC on QOL using the Post-gastrectomy Syndrome Assessment Scale-45 (PGSAS-45).
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