Publications by authors named "K Seyssel"
The adaptive response to overfeeding is associated with profound modifications of gene expression in adipose tissue to support lipid storage and weight gain. The objective of this study was to assess in healthy lean men whether a supplementation with polyphenols could interact with these molecular adaptations. Abdominal subcutaneous adipose tissue biopsies were sampled from 42 subjects participating to an overfeeding protocol providing an excess of 50% of their total energy expenditure for 31 days, and who were supplemented with 2 g/day of grape polyphenols or a placebo.
View Article and Find Full Text PDFBackground: Chronic exposure to high iron levels increases diabetes risk partly by inducing oxidative stress, but the consequences of acute iron administration on beta cells are unknown. We tested whether the acute administration of iron for the correction of iron deficiency influenced insulin secretion and the production of reactive oxygen species.
Methods: Single-center, double-blinded, randomized controlled trial conducted between June 2017 and March 2020.
Article Synopsis
- Two double-blind trials involving 42 men and 19 women assessed the impact of 2 g/day of grape polyphenol extract during a 31-day period of high calorie-high fructose overfeeding.
- While body weight and fat mass increased in both men and women, grape polyphenol supplementation did not prevent changes in insulin sensitivity or fat accumulation, particularly in the liver for men.
- Interestingly, the intake of polyphenols was linked to a decrease in fat cell size in women's femoral fat, indicating some localized effects despite overall metabolic alterations remaining unchanged.
Background & Aims: Hyperuricemia is an independent risk factor for the metabolic syndrome and cardiovascular disease. We hypothesized that asymptomatic carriers for hereditary fructose intolerance (OMIM 22960) would have increased uric acid and altered component of the metabolic syndrome when exposed to fructose overfeeding.
Methods: Six heterozygotes for HFI (hHFI) and 6 controls (Ctrl) were studied in a randomized, controlled, crossover trial.
Background: The mechanisms by which chronic stress increases the risk of non-communicable diseases remain poorly understood. On one hand, chronic stress may increase systemic vascular resistance (SVR) and blood pressure, which may lead to blood vessels injury and altered myocardial perfusion. On the other hand, chronic stress may promote the overconsumption of sugar-containing foods and favor obesity.
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