Publications by authors named "K Sentani"
Background: Urothelial carcinoma (UC) is a common type of malignant disease; however, the diagnostic and prognostic markers of upper urinary tract urothelial cancer (UTUC) remain poorly understood because of its rarity.
Methods: To clarify the clinicopathological significance of granulocyte-colony stimulating factor (G-CSF) in UTUC, we analyzed the expression and distribution of G-CSF in 112 upper tract urothelial carcinoma (UTUC) samples with immunohistochemistry.
Results: In normal urothelium, G-CSF expression was weak or absent, whereas high expression of G-CSF was observed in UTUC tissues, both in tumor cells (TCs) and stromal cells (SCs).
Article Synopsis
- Rectal neuroendocrine carcinomas (NECs) are rare tumors with a worse prognosis compared to common adenocarcinomas, and the role of adjuvant chemotherapy after surgery is not well-established.
- A 48-year-old woman diagnosed with rectal NEC following a laparoscopic resection received postoperative chemotherapy with irinotecan and cisplatin, showing no recurrence after three years.
- This case emphasizes the need for a combination of surgical and chemotherapy treatments in managing aggressive rectal NECs effectively.
Article Synopsis
- The study investigated the link between epicardial adipose tissue (EAT) characteristics and aortic valve calcification (AVC) using CT scans in 43 patients before heart surgery.
- Results showed that EAT density was positively correlated with the quantity of inflammatory macrophages and osteocalcin-positive cells, indicating a relationship between inflammation in EAT and AVC severity.
- The findings suggest that higher EAT density, along with certain immune cell counts, may indicate more severe aortic valve degeneration, highlighting the importance of EAT in cardiovascular health.
Background: Glutaminase 1 (GLS1), a key enzyme in glutamine metabolism in cancer cells, acts as a tumor promoter and could be a potential therapeutic target. CB-839, a GLS1-specific inhibitor, was developed recently. Herein, we aimed to elucidate the anti-tumor effects and mechanism of action of CB-839 in colorectal cancer (CRC).
View Article and Find Full Text PDFGastric cancer (GC) is still one of the leading causes of cancer-related mortality. We previously reported the relationship between histological heterogeneity of tumor cells and molecular features in GC. The tumor microenvironment also has a crucial role in GC progression and therapeutic resistance.
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