Publications by authors named "K Sekhar"
The assembly of low-immunogenic poly(ethylene glycol) nanoparticles (PEG NPs) for targeted delivery of therapeutics (i.e., mitoxantrone and imidazoquinoline) and improved photothermal-immunotherapy is reported.
View Article and Find Full Text PDFInjectable hydrogels, as a class of highly hydrated soft materials, are of interest for biomedicine due to their precise implantation and minimally invasive local drug delivery at the implantation site. The combination of gelation ability and versatile therapeutic agent/cell loading capabilities makes injectable hydrogels ideal materials for drug delivery, tissue engineering, wound dressing and tumor treatment. In particular, the stimuli-responsive injectable hydrogels that can respond to different stimuli in and out of the body (, temperature, pH, redox conditions, light, magnetic fields, .
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- Polyethylene glycol (PEG) modification helps reduce biofouling, but its application is limited by low PEGylation density on surfaces.* -
- The study introduces PEG brushes with different structures, finding that -phthalaldehyde (OPA) significantly increases grafting density and antifouling properties compared to benzaldehyde.* -
- The research shows that PEG-OPA and polylysine bottlebrushes improve blood circulation and tumor imaging, highlighting the importance of backbone rigidity in enhancing antifouling performance.*
Oil-in-water emulsions are extensively used in skincare products due to their improved texture, stability, and effectiveness. There is limited success in developing effective delivery systems that can selectively target the active sunscreen ingredients onto the skin surface. Herein, an organohydrogel was prepared by physical cross-linking of an oil-in-water nanoemulsion with chitosan under neutral pH conditions.
View Article and Find Full Text PDFIntrinsic hemostasis is an innate body response to prevent bleeding based on the sol-gel transition of blood. However, it is often inadequate for exceptional situations, such as acute injury and coagulation disorders, which typically require immediate medical intervention. Herein, we report the preparation of an efficient hemostatic powder, composed of tannic acid (TA), poly(ethylene glycol) (PEG), and poly(d,l-lactide--glycolide)--poly(ethylene glycol)--poly(d,l-lactide--glycolide) triblock copolymer (TB), for biomimetic hemostasis at the bleeding sites.
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