Publications by authors named "K Schwing"
We propose a set of metrics, based upon the four flows theory of the communicative constitution of organizations, to evaluate the emergence of organization in a social network. Using an agent-based model (ABM), we validate that our metrics chart the evolution of partial organizations as the population progresses from complete dissociation to unified allegiance. Our metrics allow the evaluation of organizational strength much more efficiently than previous, context-specific methods.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to investigate the presence of autoantibodies and immune cells in patients with autoimmune encephalitis (AE) by analyzing data from 94 patients who show various neuropsychological phenotypes.
- Different phenotypes were identified, with notable associations found between memory dysfunction and the presence of specific immune cells like CD8+ T-cells and CD19+ B-cells in cerebrospinal fluid (CSF).
- The findings suggest that these phenotypes, along with CSF antibody positivity, can serve as biomarkers for patient stratification, highlighting the immune response's role in the memory dysfunction associated with AE, though further research is needed for confirmation.
Combined IR and UV laser spectroscopic techniques in molecular beams merged with theoretical approaches have proven to be an ideal tool to elucidate intrinsic structural properties on a molecular level. It offers the possibility to analyze structural changes, in a controlled molecular environment, when successively adding aggregation partners. By this, it further makes these techniques a valuable starting point for a bottom-up approach in understanding the forces shaping larger molecular systems.
View Article and Find Full Text PDFObjective: Neuropsychological impairments are major symptoms of autoimmune limbic encephalitis (LE) epilepsy patients. In LE epilepsy patients with an autoimmune response against intracellular antigens as well as in antibody-negative patients, the antibody findings and magnetic resonance imaging pathology correspond poorly to the clinical features. Here, we evaluated whether T- and B-cells are linked to cognitive impairment in these groups.
View Article and Find Full Text PDFPurpose: Flow cytometry helps to elucidate the cellular immune repertoire's mechanisms in patients with temporal lobe epilepsy (TLE) due to limbic encephalitis (LE) subcategories and carries potential significance for subtype-specific treatment.
Methods: We enrolled 62 patients with TLE due to LE associated with no autoantibodies (n = 40), neural autoantibodies (n = 22), as well as autoantibodies against intracellular antigens (n = 15/22). All patients underwent neuropsychological testing, brain magnetic resonance imaging (MRI), electroencephalography (EEG) recordings, and peripheral blood (PB) and cerebrospinal fluid (CSF) investigations including flow cytometry.