Publications by authors named "K Schuetze"
Bromodomain and extraterminal domain (BET) proteins, including BRD4, bind acetylated chromatin and coactivate gene transcription. A BET inhibitor, JQ1, prevents and reverses pathological cardiac remodeling in preclinical models of heart failure. However, the underlying cellular mechanisms by which JQ1 improves cardiac structure and function remain poorly defined.
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- Geriatric comanagement for older surgical patients can enhance recovery, but successful discharge planning is crucial for ongoing care.
- The SURGE-Ahead project is focused on creating an AI-supported clinical decision support system (CDSS) to improve geriatric care in surgical settings.
- A qualitative study conducted via interviews with healthcare professionals revealed key challenges in geriatric patient care and attitudes towards an AI-CDSS, highlighting the potential benefits and ethical concerns of using AI in these processes.
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- Hip fractures continue to have high morbidity and mortality rates, and delays in surgery often occur for patients on long-term antithrombotic therapy, but urgent surgery may not lead to severe bleeding complications.
- A study reviewed 1142 patients who underwent surgery within 24 hours for hip fractures, with 51.1% on antithrombotics; it focused on transfusion rates, hemoglobin changes, mortality, and hematoma occurrences post-surgery.
- The findings revealed a 10.3-hour mean surgery wait, a 25.9% blood transfusion rate influenced by surgery duration and anticoagulants, a 5.3% mortality rate primarily linked to ASA classification and surgery timing, and 3
The current demographic development is leading to an increasing number of cases of osteoporosis-related fractures. Affected individuals are typically part of a vulnerable, predominantly geriatric patient group with limited physical resources. Additionally, the pathophysiological characteristics of osteoporotic bones with reduced bone quality and quantity, pose a significant challenge to the osteosynthesis techniques used.
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- In vitro cultures of cardiac fibroblasts (CFs) are used to study cardiac fibrosis, but the rigid plastic surfaces lead to unwanted changes in the cells that complicate research outcomes.
- Using soft PEG hydrogels to mimic the stiffness of healthy and fibrotic hearts, researchers found that low stiffness can revert activated CFs to a quiescent state, although it also increased markers of cellular aging.
- The study uncovered how CFs adapt their gene expression based on the stiffness of their environment, providing insights into how tissue rigidity influences their behavior and contributes to heart disease.