Publications by authors named "K Scholten"
T-cell lymphoblastic lymphoma (T-LBL) and T-cell acute lymphoblastic leukemia (T-ALL) have common and distinguishing clinical and molecular features. Molecular prognostic factors are needed for T-LBL. We assessed the prevalence and prognostic impact of the T-cell receptor β (TRB)::NOTCH1 fusion in 192 pediatric patients with T-LBL and 167 pediatric patients with T-ALL, using novel multiplex polymerase chain reaction and genomic capture high-throughput sequencing techniques.
View Article and Find Full Text PDFThe adoptive transfer of T cell receptor-engineered (TCR-engineered) T cells (ACT) targeting the HLA-A2-restricted cancer-testis epitope NY-ESO-1157-165 (A2/NY) has yielded favorable clinical responses against several cancers. Two approaches to improve ACT are TCR affinity optimization and T cell coengineering to express immunomodulatory molecules that can exploit endogenous immunity. By computational design we previously developed a panel of binding-enhanced A2/NY-TCRs including A97L, which augmented the in vitro function of gene-modified T cells as compared with WT.
View Article and Find Full Text PDFBackground: Endoscopic ultrasound-guided portal pressure gradient measurement (EUS-PPG) is a new modality where the portal pressure is measured by directly introducing a needle into the hepatic vein and portal vein. This is the first systematic review and meta-analysis to evaluate the efficacy and safety of EUS-PPG.
Methods: A comprehensive literature search was performed to identify pertinent studies.
Article Synopsis
- * A comprehensive analysis of 97 BCP-LBL cases revealed a mutational profile closely resembling that of BCP-ALL, though with a higher frequency of mutations in epigenetic modifiers in BCP-LBL.
- * The study found that most molecular subtypes from BCP-ALL are also present in BCP-LBL, suggesting that next-generation sequencing can help identify genetic subtypes in BCP-LBL, potentially
Article Synopsis
- Idiopathic granulomatous hepatitis is a rare liver condition that causes symptoms like recurrent fevers, muscle pain, and enlarged liver/spleen without any infectious cause.
- Traditional treatment involves steroids, which often relieve symptoms quickly but can lead to recurrences when tapered off; alternative medications like azathioprine and methotrexate can be effective.
- This case study presents a patient who developed antibodies against common treatments infliximab and adalimumab, marking the first successful use of certolizumab pegol for managing this condition, demonstrating its effectiveness against idiopathic granulomatous hepatitis and related antibodies.