Publications by authors named "K Schober"
Article Synopsis
- The study focuses on ventricular pre-excitation (VPE) in cats, which occurs when abnormal electrical pathways cause premature ventricle excitation, leading to a specific type of rapid heart rate known as orthodromic atrioventricular reciprocating tachycardia (SVT).
- The research analyzed 23 cats diagnosed with VPE from 2010 to 2022, reviewing their clinical signs, ECG results, treatments, and outcomes.
- Results showed that most cats experienced symptoms like collapse and respiratory distress, and the median survival time after diagnosis was a favorable 5.1 years, indicating a generally good prognosis for affected cats.
Article Synopsis
- A two-year-old male cat was brought to a veterinary center after showing sudden neurological symptoms and was diagnosed with stage B1 hypertrophic cardiomyopathy via echocardiogram.
- His condition worsened, leading to seizures and panting, ultimately resulting in euthanasia.
- A necropsy revealed a rare condition called systemic reactive angioendotheliomatosis, highlighting the risk of misdiagnosing heart issues in cats based solely on echocardiographic findings.
Epigenetic mechanisms stabilize gene expression patterns during CD8+ T cell differentiation. Although adoptive transfer of virus-specific T cells is clinically applied to reduce the risk of virus infection or reactivation in immunocompromised individuals, the DNA methylation pattern of virus-specific CD8+ T cells is largely unknown. Hence, we here performed whole-genome bisulfite sequencing of cytomegalovirus-specific human CD8+ T cells and found that they display a unique DNA methylation pattern consisting of 79 differentially methylated regions (DMRs) when compared to memory CD8+ T cells.
View Article and Find Full Text PDFMitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies. Here, we describe an innovative platform to supply exogenous mitochondria to T cells, overcoming these limitations. We found that bone marrow stromal cells establish nanotubular connections with T cells and leverage these intercellular highways to transplant stromal cell mitochondria into CD8 T cells.
View Article and Find Full Text PDFLow antigen sensitivity and a gradual loss of effector functions limit the clinical applicability of chimeric antigen receptor (CAR)-modified T cells and call for alternative antigen receptor designs for effective T cell-based cancer immunotherapy. Here, we applied advanced microscopy to demonstrate that TCR/CD3-based synthetic constructs (TCC) outperform second-generation CAR formats with regard to conveyed antigen sensitivities by up to a thousandfold. TCC-based antigen recognition occurred without adverse nonspecific signaling, which is typically observed in CAR-T cells, and did not depend-unlike sensitized peptide/MHC detection by conventional T cells-on CD4 or CD8 coreceptor engagement.
View Article and Find Full Text PDF