[Terminal DNA nucleotidyltransferase in blastic crisis in myelocytic leukemia].

The importance of determination of the activity of TdT is discussed in the light of a case of chronic myeloid leukaemia in a patient aged 55 years in whom after 4 years from the onset of the disease blastic crisis developed. High TdT activity was correlated with other features of blastic crisis of lymphoid character and with good response to vincristine and prednisone. This enzyme which is a valuable marker of lymphoblasts can predict also blastic crisis and give cues as to proper treatment.

Adoptive immunotherapy and combined chemo-immunotherapy in transplantable leukaemia of AKR mice (TAL); occurrence of natural killers.

Allo- and syngeneic lymphoid effector cells were injected I. P. into transplantable leukaemia (TAL)-bearing AKR recipients.

[Pros and cons of the use of immunotherapeutic procedures with special reference to adoptive immunotherapy in proliferative diseases].

Consequences, results, and side-effects known today about active and passive as well as adoptive immunotherapy in human neoplastic diseases are described in a survey and discussed in view of the experiences obtained by animal experiments. In this connection, special attention is attributed to restoring the haematopoietic function by bone-marrow transplantation or implantation of thymus tissue from an immunological point of view.